स्वप्रतिरक्षित रोग

स्वप्रतिरक्षित रोग 28805 D84.9, M35.9 279.4 109100 000816 D001327 वे रोग स्वप्रतिरक्षित रोग (Autoimmune diseases) कहलाते हैं जिनके होने पर किसी जीव की प्रतिरक्षा प्रणाली अपने ही ऊतकों या शरीर में उपस्थित अन्य पदार्थों को रोगजनक (pathogen) समझने की गलती कर बैठती है और उन्हें समाप्त करने के लिये उन पर हमला कर देती है। इस प्रकार का रोग शरीर के किसी एक अंग में सीमित हो सकता है (जैसे स्वप्रतिरक्षित थॉयराय शोथ (autoimmune thyroiditis) या शरीर के विभिन्न स्थानों पर एक विशेष प्रकार के ऊतक को प्रभावित कर सकता है। स्वप्रतिरक्षित रोगों की चिकित्सा में प्रायः दवाओं का उपयोग करके प्रतिरक्षा प्रणाली की सक्रियता को कम किया जाता है जिसे प्रतिरक्षादमन (immunosuppression) कहते हैं। मानदण्ड (क्राइटेरिया) वर्गीकरण नाम Accepted/suspected Hypersensitivity I, II, III, IV आटोएन्टीबॉडी टिप्पणी Acute disseminated encephalomyelitis (ADEM) AcceptedAutoimmune+Diseases Addison's disease interferon omega; transglutaminase; aromatic acid carboxylase; GAD; HAI; 17 hydroxylase; 21 hydroxylase Agammaglobulinemia IGHM; IGLL1: CD79A; CD79B; BLNK; LRRC8A Alopecia areata AcceptedAmerican Academy of Dermatology, http://www.aad.org/public/publications/pamphlets/common_alopecia.html https://web.archive.org/web/20100706154955/http://www.aad.org/public/publications/pamphlets/common_alopecia.html 6 जुलाई 2010 htmlThe University of Texas MD Anderson Cancer Center, http://www.mdanderson.org/patient-and-cancer-information/cancer-information/cancer-types/alopecia-areata/index.html https://web.archive.org/web/20111105023305/http://www.mdanderson.org/patient-and-cancer-information/cancer-information/cancer-types/alopecia-areata/index.html 5 नवंबर 2011 T-cells Amyotrophic Lateral Sclerosis Ankylosing Spondylitis AcceptedHLA-B27 and Ankylosing Spondylitis, http://www.hlab27.com https://web.archive.org/web/20190829171719/http://hlab27.com/ 29 अगस्त 2019 Inflammatory Diseases of Immune Dysregulation, http://www.idid.us https://web.archive.org/web/20180308114047/http://www.idid.us/ 8 मार्च 2018 Khan MA, Khan MK Diagnostic Value of HLA-B27 Testing in Ankylosing Spondylitis and Reiter's Syndrome Annals of Internal Medicine January 1, 1982 vol. 96 no. 1 70-76 96 1 70–76; author reply 76 1982 7053711 ANCA? CD8; HLA-B27 Antiphospholipid syndrome Accepted anti-cardiolipin;anti pyruvate dehydrogenase; β2 glycoprotein I; phosphatidylserine; anti apoH; Annexin A5 HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3 Antisynthetase syndrome Atopic allergy I Atopic dermatitis I Autoimmune aplastic anemia Autoimmune cardiomyopathy Accepted Autoimmune enteropathy Autoimmune hemolytic anemia Accepted II complement activation Autoimmune hepatitis Accepted cell-mediatedanti-mitochondrial antibodies; ANA; anti-smooth muscle antibodies, LKM-1; soluble liver antigen Autoimmune inner ear disease Accepted http://www.bcm.edu/oto/grand/4893.html Autoimmune Inner Ear Disease, Baylor College of Medicine 1993 1 जुलाई 2012 https://web.archive.org/web/20080517030514/http://www.bcm.edu/oto/grand/4893.html 17 मई 2008 live Autoimmune lymphoproliferative syndrome Accepted TNFRSF6; defective Fas-CD95 apoptosis Autoimmune peripheral neuropathy Accepted Autoimmune pancreatitis Accepted ANA; anti-lactoferrin antibodiesanti-carbonic anhydrase antibodies; rheumatoid factor Autoimmune polyendocrine syndrome Accepted Unknown or multiple APS-1 see Addison's disease Autoimmune progesterone dermatitis Accepted Autoimmune thrombocytopenic purpura Accepted anti gpIIb-IIIa or 1b-IX Autoimmune urticaria Accepted Soundararajan S, Kikuchi Y, Kusumam J, Kaplan AP Functional | assessment of pathogenic IgG subclass in chronic autoimmune urticaria Journal of Allergy and Clinical 115 4 815–21 2004 10.1016/j.jaci.2004.12.1120 Immunology Autoimmune uveitis Accepted HLAB-27? Balo disease/Balo concentric sclerosis Behçet's disease immune-mediated systemic vasculitis; linkage to HLA-B51 (HLA-B27); very different manifestations with ulcers as common symptom; also called Morbus Adamandiades-Behçet Berger's disease IgA (elevated in 50% of patients), IgA (in mesangial deposits on kidney biopsy) Bickerstaff's encephalitis Anti-GQ1b 2/3 patients similar to Guillain-Barré syndrome Blau syndrome overlaps both sarcoidosis and granuloma annulare Bullous pemphigoid IgG autoantibodies targeting the type XVII collagen component of hemidesmosomes http://www.merckmanuals.com/home/immune_disorders/autoimmune_disorders/autoimmune_disorders.html Autoimmune Disorders: Immune Disorders: Merck Manual Home Health Handbook https://web.archive.org/web/20120712224748/http://www.merckmanuals.com/home/immune_disorders/autoimmune_disorders/autoimmune_disorders.html 12 जुलाई 2012 live Cancer Castleman's disease Over expression of IL-6 सीलिएक रोग Acceptedhttp://digestive.niddk.nih.gov/ddiseases/pubs/celiac/#1 Celiac Disease https://web.archive.org/web/20090720193635/http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/#1 20 जुलाई 2009 dead Meize-Grochowski R Celiac disease: a multisystem autoimmune disorder Gastroenterol Nurs 28 5 394–402; quiz 403–4 2005 16234635 10.1097/00001610-200509000-00005 http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1042-895X&volume=28&issue=5&spage=394 1 जुलाई 2012 https://web.archive.org/web/20120311155225/http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1042-895X&volume=28&issue=5&spage=394 11 मार्च 2012 live Sollid LM, Jabri B Is celiac disease an autoimmune disorder? Curr. Opin. Immunol. 17 6 595–600 2005 December 16214317 10.1016/j.coi.2005.09.015 http://linkinghub.elsevier.com/retrieve/pii/S0952-7915(05)00158-5 1 जुलाई 2012 https://web.archive.org/web/20191217040926/https://linkinghub.elsevier.com/retrieve/pii/S0952-7915(05)00158-5 17 दिसंबर 2019 dead IV?? Anti-tissue transglutaminase antibodies HLA-DQ8 and DQ2.5 Chagas disease SuspectedHyland KV, Engman DM Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease https://archive.org/details/sim_trends-in-parasitology_2006-03_22_3/page/101 Trends Parasitol. 22 3 101–2; author reply 103 2006 16446117 10.1016/j.pt.2006.01.001 Chronic inflammatory demyelinating polyneuropathy Anti-ganglioside antibodies:anti-GM1, anti-GD1a, anti-GQ1bsimilar to Guillain-Barré syndrome Chronic recurrent multifocal osteomyelitis LPIN2, D18S60,similar to Majeed syndrome Chronic obstructive pulmonary disease SuspectedAgustí A, MacNee W, Donaldson K, Cosio M. Hypothesis: does COPD have an autoimmune component? https://archive.org/details/sim_thorax_2003-10_58_10/page/832 Thorax 58 10 832–834 2003 14514931 10.1136/thorax.58.10.832 1746486Lee SH, Goswami S, Grudo A, et al Antielastin autoimmunity in tobacco smoking-induced emphysema Nat. Med. 13 5 567–9 2007 17450149 10.1038/nm1583 Churg-Strauss syndrome p-ANCA Cicatricial pemphigoid anti-BP-1, anti BP-2precipitates C3 Cogan syndrome Cold agglutinin disease Accepted II IgMidiopathic or secondary to leukemia or infection Complement component 2 deficiency Contact dermatitis III Cranial arteritis aka Temporal arteritis; involves giant cells CREST syndrome Anti-centromere antibodies Anti-nuclear antibodies Crohn's disease (one of two types of idiopathic inflammatory bowel disease "IBD") Accepted IV Innate immunity; Th17; Th1; ATG16L1; CARD15;XBP1; Cushing's Syndrome cortisol binding globulin? Cutaneous leukocytoclastic angiitis neutrophils Dego's disease Vasculopathy Dercum's disease Suspected Lipoid tissue.Singal A, Janiga JJ, Bossenbroek NM, Lim HW Dercum's disease (adiposis dolorosa): a report of improvement with infliximab and methotrexate J Eur Acad Dermatol Venereol 21 5 717 2007 May 17448013 10.1111/j.1468-3083.2006.02021.x http://doi.org/10.1111/j.1468-3083.2006.02021.x Dermatitis herpetiformis IgA; anti-epidermal transglutaminase antibodies Dermatomyositis Acceptedhttp://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/polymyositis_and_dermatomyositis.html Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook https://web.archive.org/web/20120704075741/http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/polymyositis_and_dermatomyositis.html 4 जुलाई 2012 live histidine-tRNA anti-signal recognition peptide Anti-Mi-2 Anti-Jo1.Ghirardello A Zampieri S, Tarricone E et al. Clinical implications of autoantibody screening in patients with autoimmune myositis Autoimmunity 39 3 217–221 May 2006 16769655 10.1080/08916930600622645 B- and T-cell perivascular inflammatory infiltrate on muscle biopsy टाइप 1 डायबिटीज मेलेटस Accepted IV Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), and insulinoma-associated autoantibodies (IA-2), anti-insulin antibodies Diffuse cutaneous systemic sclerosis anti-nuclear antibodies, anti-centromere and anti-scl70/anti-topoisomerase antibodiesJimenez SA, Derk CT Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis https://archive.org/details/sim_annals-of-internal-medicine_2004-01-06_140_1/page/n78 Ann. Intern. Med. 140 1 37–50 2004 14706971 COL1A2 and TGF-β1 Dressler's syndrome myocardial neo-antigens formed as a result of the MI Drug-induced lupus anti-histone Discoid lupus erythematosus III IL-2 and IFN-gamma>Toro JR, Finlay D, Dou X, Zheng SC, LeBoit PE, Connoly KM Detection of Type 1 Cytokines in Discoid Lupus Erythematosus Annals of Internal Medicine 2000 136 1497–1501 Eczema LEKTI, SPINK5,Walley AJ, Chavanas S, Moffatt MF, et al. Gene polymorphism in Netherton and common atopic disease Nat. Genet. 29 2 175–8 2001 11544479 10.1038/ng728 filaggrin.,Palmer CN et al. 2006 Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis Nature Genetics 38 4 441–6 16550169 10.1038/ng1767 Brain-derived neurotrophic factor (BDNF) and Substance P. 'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities http://news.bbc.co.uk/2/hi/health/6962450.stm 26 अगस्त 2007 बीबीसी न्यूज़ 16 अक्टूबर 2007 https://web.archive.org/web/20171209003749/http://news.bbc.co.uk/2/hi/health/6962450.stm 9 दिसंबर 2017 live Endometriosis SuspectedGleicher N, el-Roeiy A, Confino E, Friberg J Is endometriosis an autoimmune disease? https://archive.org/details/sim_obstetrics-and-gynecology_1987-07_70_1/page/115 Obstetrics and gynecology 70 1 115–22 1987 3110710 Enthesitis-related arthritisColbert RA Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond Nat Rev Rheumatol. 2010 Aug 6 8 477–85 10.1038/nrrheum.2010.103 2010 .MMP3Viswanath V, Myles A, Dayal R, Aggarwal A Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis J Rheumatol 2011 Sep1 TRLR2, TLR4, Myles A, Aggarwal A Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis Rheumatology (Oxford) 2011 Mar 50 3 481–8 21097451 10.1093/rheumatology/keq362 2011 March ERAP1Hinks A, Martin P, Flynn E, Eyre S, Packham J; Childhood Arthritis Prospective Study (CAPS); BSPAR study group, Barton A, Worthington J, Thomson W. Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis Arthritis Res Ther 2001 13 1 R12 21281511 10.1186/ar3235 3241356 Eosinophilic fasciitis Accepted Eosinophilic gastroenteritis IgE IL-3, IL-5, GM-CSF, eotaxin Epidermolysis bullosa acquisita COL7A1 Erythema nodosum Erythroblastosis fetalis II ABO, Rh, Kell antibodies mother's immune system attacks fetus Essential mixed cryoglobulinemia Evan's syndrome Fibrodysplasia ossificans progressiva ACVR1 Lymphocytes express increased BMP4 Fibrosing alveolitis (or Idiopathic pulmonary fibrosis) SFTPA1, SFTPA2, TERT, and TERC.178500 Gastritis serum antiparietal and anti-IF antibodies Gastrointestinal pemphigoid Accepted Giant cell arteritis macrophage giant cells Glomerulonephritis Sometimes IgA see Buerger's disease for IgA; Membranous glomerulonephritis for IgG; Membranoproliferative/mesangiocapillary GN (Complement activation); Goodpasture's syndrome; Wegener's granulomatosis Goodpasture's syndrome Accepted II Anti-Basement Membrane Collagen Type IV Protein Graves' disease Accepted II thyroid autoantibodies (TSHR-Ab) that activate the TSH-receptor (TSHR) Guillain-Barré syndrome (GBS) Accepted IV Anti-ganglioside Hashimoto's encephalopathy Accepted IV alpha-enolase 17335908 10.1016/j.jneuroim.2007.01.018 185 1–2 High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy 2007 April J. Neuroimmunol. 195–200 Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M Hashimoto's thyroiditis Accepted IV antibodies against thyroid peroxidase and/or thyroglobulin HLADR5, CTLA-4 Henoch-Schonlein purpura immunoglobulin A (IgA) and complement component 3 (C3) Herpes gestationis aka Gestational Pemphigoid IgG and C3 misdirected antibodies intended to protect the placenta Hidradenitis suppurativa Suspectedhttp://clinicaltrials.gov/show/NCT00329823 Clinical Trial: Etanercept in Hidradenitis Suppurativa 8 जुलाई 2007 https://web.archive.org/web/20071012140629/http://clinicaltrials.gov/show/NCT00329823 12 अक्तूबर 2007 live Hughes-Stovin syndrome Hypogammaglobulinemia IGHM, IGLL1, CD79A, BLNK, LRRC8A, CD79B Idiopathic inflammatory demyelinating diseases a variant of multiple sclerosis Idiopathic pulmonary fibrosis SFTPA1, SFTPA2, TERT, and TERC. Idiopathic thrombocytopenic purpura (See Autoimmune thrombocytopenic purpura) Accepted II glycoproteins IIb-IIIa or Ib-IX, immunoglobulin G IgA nephropathy III? IgA produced from marrow rather than MALT Inclusion body myositis similar to polymyositis but does not respond to steroid therapy-activated T8 cells Chronic inflammatory demyelinating polyneuropathy anti-ganglioside antibodies similar to Guillain–Barré syndrome Interstitial cystitis SuspectedKárpáti F, Dénes L, Büttner K [Interstitial cystitis=autoimmune cyatitis? Interstitial as a participating disease in lupus erythematosus] de Zeitschrift für Urologie und Nephrologie 68 9 633–9 1975 1227191 Mast cells Juvenile idiopathic arthritis aka Juvenile rheumatoid arthritis inconsistent ANA Rheumatoid factor Kawasaki's disease Suspected ITPKC HLA-B51 Lambert-Eaton myasthenic syndrome voltage-gated calcium channels; Q-type calcium channel, synaptogagmin, muscarinic acetylcholine receptor M1 HLA-DR3-B8 Leukocytoclastic vasculitis Lichen planus Lichen sclerosus Linear IgA disease (LAD) Lou Gehrig's disease (Also Amyotrophic lateral sclerosis) VCP, ATXN2, OPTN, FIG4, TARDBP, ANG, VAPB, FUS, SETX, ALS2, SOD1 Lupoid hepatitis aka Autoimmune hepatitis ANA and SMA,Bogdanos DP, Invernizzi P, Mackay IR, Vergani D Autoimmune liver serology: Current diagnostic and clinical challenges World J. Gastroenterol. 14 21 3374–3387 2008 June 18528935 10.3748/wjg.14.3374 http://www.wjgnet.com/1007-9327/14/3374.asp 2716592 1 जुलाई 2012 https://web.archive.org/web/20160528222404/http://www.wjgnet.com/1007-9327/14/3374.asp 28 मई 2016 live LKM-1, LKM-2 or LKM-3; antibodies against soluble liver antigenhttp://www.meddean.luc.edu/Lumen/MedEd/orfpath/autoimmune%20hepatitis.htm autoimmune hepatitis https://web.archive.org/web/20120701203114/http://www.meddean.luc.edu/lumen/MedEd/orfpath/autoimmune%20hepatitis.htm 1 जुलाई 2012 live http://www.medscape.com/viewarticle/445619_14 Medscape & eMedicine Log In https://web.archive.org/web/20120403205153/http://www.medscape.com/viewarticle/445619_14 3 अप्रैल 2012 live (anti-SLA, anti-LP) no autoantibodies detected (~20%)जुलाई 2008 Lupus erythematosus Accepted III Anti-nuclear antibodiesEhrenstein MR Antinuclear antibodies and lupus: causes and consequences Rheumatology (Oxford) 38 8 691–3 1999 August 10501412 10.1093/rheumatology/38.8.691 http://rheumatology.oxfordjournals.org/content/38/8/691.full 1 जुलाई 2012 https://web.archive.org/web/20150930181635/http://rheumatology.oxfordjournals.org/content/38/8/691.full 30 सितंबर 2015 dead anti-Ro.15804706 Also, they are often present in Sjögren's syndrome.Franceschini F, Cavazzana I Anti-Ro/SSA and La/SSB antibodies Autoimmunity 38 1 55–63 2005 February 15804706 10.1080/08916930400022954 1868868 Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome V Goëb et al. 2007 10.1111/j.1365-2249.2007.03337.x 17286756 148 2 Clin. Exp. Immunol. 281–7 Majeed syndrome LPIN2 Ménière's disease III? major peripheral myelin protein P0Boulassel MR, Deggouj N, Tomasi JP, Gersdorff M. Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases.| journa;=Acta Otolaryngol 12 1 28–34. 2001 Jan Microscopic polyangiitis p-ANCA myeloperoxidase binds to neutrophils causing them to degranulate and damages endothelium Miller-Fisher syndrome see Guillain-Barre Syndrome Accepted anti-GQ1b Mixed connective tissue disease Accepted anti-nuclear antibody anti-U1-RNP HLA-DR4 Morphea SuspectedTakehara K, Sato S Localized scleroderma is an autoimmune disorder https://archive.org/details/sim_rheumatology_2005-03_44_3/page/274 Rheumatology (Oxford, England) 44 3 274–9 2005 15561734 10.1093/rheumatology/keh487 Mucha-Habermann disease aka Pityriasis lichenoides et varioliformis acuta T-cells Multiple sclerosis Suspected IV PECAM-1 Kalinowska A, Losy J. PECAM-1, a key player in neuroinflammation Eur J Neurol 13 12 1284–90274 2006 17116209 10.1111/j.1468-1331.2006.01640.x Anti-Myelin Basic Protein Myasthenia gravis Accepted II nicotinic acetylcholine receptor MuSK proteinHA-B8 HLA-DR3 HLA-DR1 Myositis see Dermatomyositis and Polymyositis see Inclusion-body-myositis NarcolepsyHallmayer J, Faraco J, Lin L, et al. Narcolepsy is strongly associated with the TCR alpha locus Nat. Genet. 41 6 708–11 2009 June 19412176 10.1038/ng.372 2803042http://www.eurekalert.org/pub_releases/2009-05/sumc-nia042809.php Narcolepsy is an autoimmune disorder, Stanford researcher says 3 मई 2009 EurekAlert American Association for the Advancement of Science 31 मई 2009 https://web.archive.org/web/20090510122328/http://www.eurekalert.org/pub_releases/2009-05/sumc-nia042809.php 10 मई 2009 live SuspectedCarlander, B., Eliaou J.F., Billiard M. Autoimmune hypothesis in narcolepsy Neurophysiol. Clin. 23 1993 10.1016/S0987-7053(05)80279-5 15–22 8446070 1 II? hypocretin or orexinMignot E 2001 A commentary on the neurobiology of the hypocretin/orexin system Neuropsychopharmacology 25 S5–13 11682267 5 Suppl 10.1016/S0893-133X(01)00316-5 S5–13 HLA-DQB1*0602Maret S Tafti M Genetics of narcolepsy and other major sleep disorders Swiss Medical Weekly 135 45–46 662–5 EMH Swiss Medical Publishers Ltd. November 2005 http://www.smw.ch/docs/pdf200x/2005/45/smw-11162.pdf PDF 16453205 7 मार्च 2008 https://web.archive.org/web/20080414122100/http://www.smw.ch/docs/pdf200x/2005/45/smw-11162.pdf 14 अप्रैल 2008 live Neuromyelitis optica (also Devic's disease) II? NMO-IgG aquaporin 4.Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel J. Exp. Med. 202 4 473–477 2005 16087714 10.1084/jem.20050304 http://www.jem.org/cgi/content/full/202/4/473 2212860 1 जुलाई 2012 https://web.archive.org/web/20071212002359/http://www.jem.org/cgi/content/full/202/4/473 12 दिसंबर 2007 live Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression Arch. Neurol. 63 7 964–968 2006 16831965 10.1001/archneur.63.7.964 http://archneur.ama-assn.org/cgi/content/full/63/7/964 1 जुलाई 2012 https://web.archive.org/web/20110928061436/http://archneur.ama-assn.org/cgi/content/full/63/7/964 28 सितंबर 2011 live Neuromyotonia SuspectedMaddison P Neuromyotonia Clinical Neurophysiology 117 10 2118–27 2006 16843723 10.1016/j.clinph.2006.03.008 II? voltage-gated potassium channels. Occular cicatricial pemphigoid II? BP-1, BP-2 C3 deposition Opsoclonus myoclonus syndrome Suspected IV? Lymphocyte recruitment to CSFPranzatelli, M. R., Travelstead, A. L., Tate, E. D., Allison, T. J.,Moticka, E. J., Franz, D. N., Nigro, M. A., Parke, J. T., Stumpf, D. A., Verhulst, S. J. B- and T-cell markers in opsoclonus-myoclonus syndrome: Immunophenotyping of CSF lymphocytes https://archive.org/details/sim_neurology_2004-05-11_62_9/page/n132 Neurology 62 1526–1532 2004 15136676 62 9 Ord's thyroiditis Palindromic rheumatism anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA)Powell A, Davis P, Jones N, Russell AS Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients J. Rheumatol. 35 6 992–4 2008 June 18412310 http://www.jrheum.com/subscribers/08/06/992.html 1 जुलाई 2012 https://web.archive.org/web/20160304065825/http://www.jrheum.com/subscribers/08/06/992.html 4 मार्च 2016 dead PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus) Suspected II? antibodies against streptococcal infection serve as auto-antibodies Paraneoplastic cerebellar degeneration IV?Proc Natl Acad Sci U S A Darnell,R.B. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain 93 10 4529–4536 1996 8643438 39311 II? anti-YoNeurology Peterson,K., Rosenblum, J.K., Kotanides,H., Posner,J.B. Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients 42 10 1931–1937 1992 1407575 (anti-cdr-2Ann Neurol Albert,M.L., Austin,L.M., Darnell,R.B. Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration 47 1 9–17 2000 10632096 in purkinje fibers) anti-Hu, anti-Tr, antiglutamate receptor Paroxysmal nocturnal hemoglobinuria (PNH) Sometimes(?) complement attacks RBCs Parry Romberg syndrome ANA Parsonage-Turner syndrome Pars planitis Pemphigus vulgaris Accepted II Anti-Desmoglein 3 Pernicious anaemia Acceptedhttp://www.nlm.nih.gov/medlineplus/ency/article/000569.htm MedlinePlus Medical Encyclopedia: Pernicious anemia 5 अप्रैल 2008 https://web.archive.org/web/20080509193114/http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm 9 मई 2008 live II anti-parietal cell antibody Perivenous encephalomyelitis POEMS syndrome interleukin 1β, interleukin 6 and TNFα. vascular endothelial growth factor (VEGF), given the .Dispenzieri A, Kyle RA, Lacy MQ, et al. POEMS syndrome: definitions and long-term outcome Blood 101 7 2496–506 2003 12456500 10.1182/blood-2002-07-2299 http://bloodjournal.hematologylibrary.org/cgi/content/full/101/7/2496 1 जुलाई 2012 https://web.archive.org/web/20090125113632/http://bloodjournal.hematologylibrary.org/cgi/content/full/101/7/2496 25 जनवरी 2009 dead Polyarteritis nodosa Polymyalgia rheumatica Polymyositis Accepted IFN-gamma, IL-1, TNF-alpha Primary biliary cirrhosis Acceptedhttp://www.merckmanuals.com/home/liver_and_gallbladder_disorders/fatty_liver_cirrhosis_and_related_disorders/primary_biliary_cirrhosis.html Primary Biliary Cirrhosis: Fatty Liver, Cirrhosis, and Related Disorders: Merck Manual Home Health Handbook 5 अप्रैल 2008 https://web.archive.org/web/20120626052556/http://www.merckmanuals.com/home/liver_and_gallbladder_disorders/fatty_liver_cirrhosis_and_related_disorders/primary_biliary_cirrhosis.html 26 जून 2012 live Anti-p62, Anti-sp100, Anti-Mitochondrial(M2)Anti-Ro aka SSA. Also, they are often present in Sjögren's syndrome. Primary sclerosing cholangitis overlap with primary biliary cirrhosis? Progressive inflammatory neuropathy Suspected Psoriasis AcceptedNational Psoriasis Foundation, http://www.psoriasis.org/home/learn01.php https://web.archive.org/web/20161019155204/https://www.psoriasis.org/home/learn01.php 19 अक्तूबर 2016 IV? CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB Psoriatic arthritis AcceptedNational Psoriasis Foundation, http://www.psoriasis.org/home/learn02.php https://web.archive.org/web/20161019153505/https://www.psoriasis.org/home/learn02.php 19 अक्तूबर 2016 IV? HLA=B27 Pyoderma gangrenosum Can occur in conjunction with other immune-related disorders Pure red cell aplasia Rasmussen's encephalitis anti-NR2A antibodies Raynaud phenomenon Suspected Can occur in conjunction with other immune-related disorders Relapsing polychondritis Acceptedhttp://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/relapsing_polychondritis.html Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook https://web.archive.org/web/20120714064028/http://www.merckmanuals.com/home/bone_joint_and_muscle_disorders/autoimmune_disorders_of_connective_tissue/relapsing_polychondritis.html 14 जुलाई 2012 live Reiter's syndrome Restless leg syndrome Suspected May occur in Sjögren's syndrome, celiac disease, and rheumatoid arthritis or in derangements of iron metabolism Retroperitoneal fibrosis Rheumatoid arthritis Accepted III Rheumatoid factor (anti-IgGFc), Anti-MCV, ACPAs(Vimentin HLA-DR4, PTPN22, depleted B cells, TNF alpha, IL-17, (also maybe IL-1, 6, and 15) Rheumatic fever II streptococcal M protein cross reacts with human myosin,Faé KC, da Silva DD, Oshiro SE, et al. Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease J. Immunol. 176 9 5662–70 2006 May 16622036 http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16622036 1 जुलाई 2012 https://web.archive.org/web/20200407060205/https://www.jimmunol.org/content/176/9/5662.long 7 अप्रैल 2020 live anti-DNase B, ASO Sarcoidosis Suspected IV http://www.emedicine.com/MED/topic1100.htm eMedicine - Hypersensitivity Reactions, Delayed : Article by Walter Duane Hinshaw 18 सितंबर 2008 https://web.archive.org/web/20080915175714/http://www.emedicine.com/MED/topic1100.htm 15 सितंबर 2008 deadMorell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis Chest 121 4 1239–44 2002 April 11948059 10.1378/chest.121.4.1239 http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=11948059 1 जुलाई 2012 7 मई 2020 https://web.archive.org/web/20200507065425/http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=11948059 dead BTNL2; HLA-B7-DR15; HLA DR3-DQ2.Grunewald J, Eklund A, Olerup O Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients https://archive.org/details/american-journal-respiratory-critical-care-medicine_2004_169_1-6/page/696 Am. J. Respir. Crit. Care Med. 169 6 696–702 2004 March 14656748 10.1164/rccm.200303-459OC Schizophrenia SuspectedEaton WW, Byrne M, Ewald H, et al Association of schizophrenia and autoimmune diseases: linkage of Danish national registers https://archive.org/details/sim_american-journal-of-psychiatry_2006-03_163_3/page/521 The American Journal of Psychiatry 163 3 521–8 2006 16513876 10.1176/appi.ajp.163.3.521Jones AL, Mowry BJ, Pender MP, Greer JM Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? https://archive.org/details/sim_immunology-and-cell-biology_2005-02_83_1/page/9 Immunol. Cell Biol. 83 1 9–17 2005 15661036 10.1111/j.1440-1711.2005.01305.xStrous RD, Shoenfeld Y Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited J. Autoimmun. 27 2 71–80 2006 16997531 10.1016/j.jaut.2006.07.006 Schmidt syndrome another form of APS anti-21 hydroxylase, anti-17 hydroxylasede Carmo Silva R, Kater CE, Dib SA, et al Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III Eur. J. Endocrinol. 142 2 187–94 2000 February 10664529 10.1530/eje.0.1420187 http://eje-online.org/cgi/pmidlookup?view=long&pmid=10664529 25 जुलाई 2008 https://web.archive.org/web/20200314081639/https://testlogin.metso.com/uas/authn/*/view?_id=53002149-53cf-48d2-94bd-21fda96e972e&entityID=c9969461-0c5b-4f33-8b89-a71fb76d9b79&locale=en 14 मार्च 2020 live DQ2, DQ8 and DRB1*0404 Schnitzler syndrome IgM? Scleritis Scleroderma Suspected IV? Scl-70 Anti-topoisomerase dysregulated apoptosis? Serum Sickness III Sjögren's syndrome Accepted Anti-ro. Also, they are often present in Sjögren's syndrome. Spondyloarthropathy HLA-B27 Still's disease see Juvenile Rheumatoid Arthritis ANA macrophage migration inhibitory factorDe Benedetti F, Meazza C, Vivarelli M, et al. Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis Arthritis Rheum. 48 5 1398–407 2003 May 12746913 10.1002/art.10882 Stiff person syndrome Suspected glutamic acid decarboxylase (GAD),Murinson BB Stiff-person syndrome Neurologist 2004 131–7 10 3 15140273 10.1097/01.nrl.0000126587.37087.1a GLRA1 (glycine receptor Subacute bacterial endocarditis (SBE) IIIJ. Am. Soc. Nephrol. 8 12 1971–6 1997 December 9402102 http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=9402102 essential mixed cryoglobulinemia Susac's syndrome Sweet's syndrome GCSF Sydenham chorea see PANDAS Sympathetic ophthalmia ocular antigens following trauma Systemic lupus erythematosis see Lupus erythematosis III Takayasu's arteritis Temporal arteritis (also known as "giant cell arteritis") Accepted IV Thrombocytopenia II glycoproteins IIb-IIIa or Ib-IX in ITP anti-ADAMTS13 in TTP.Moake JL von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura Semin. Hematol. 41 1 4–14 2004 14727254 10.1053/j.seminhematol.2003.10.003 and HUS anti-cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I in Antiphospholipid syndrome anti-HPA-1a, anti-HPA-5b, and others Mueller-Eckhardt C, Kiefel V, Grubert A, Kroll H, Weisheit M, Schmidt S et al. 1989 348 cases of fetal alloimmune thrombocytopenia https://archive.org/details/sim_the-lancet_1989-02-18_1_8634/page/n27 Lancet 1 8634 363–6 10.1016/S0140-6736(89)91733-9 2563515 in NAIT multiple mechanisms Tolosa-Hunt syndrome Transverse myelitis Accepted Transverse Myelitis is a rare neurological disorder that is part of a spectrum of neuroimmunologic diseases of the central nervous system. https://web.archive.org/web/20120623100725/http://www.myelitis.org/ Ulcerative colitis (one of two types of idiopathic inflammatory bowel disease "IBD") Accepted IV Undifferentiated connective tissue disease different from Mixed connective tissue disease Accepted anti-nuclear antibody HLA-DR4 Undifferentiated spondyloarthropathy Urticarial vasculitis II? anti C1q antibodiesWisnieski JJ, Naff GB Serum IgG antibodies to C1q in hypocomplementemic urticarial vasculitis syndrome Arthritis Rheum 32 9 1119–27 1989 September 2528353 10.1002/anr.1780320910 clinically may resemble type I hypersensitivity! Vasculitis Accepted III sometimes ANCA Vitiligo Suspectedhttp://www.niams.nih.gov/hi/topics/vitiligo/vitiligo.htm Questions and Answers about Vitiligo 6 अगस्त 2007 https://web.archive.org/web/20070808050044/http://www.niams.nih.gov/hi/topics/vitiligo/vitiligo.htm 8 अगस्त 2007 live http://dermatology.jwatch.org/cgi/content/full/2007/330/1 A New Gene Linked to Vitiligo and Susceptibility to Autoimmune Disorders - Journal Watch Dermatology 6 अगस्त 2007 https://web.archive.org/web/20070903191751/http://dermatology.jwatch.org/cgi/content/full/2007/330/1 3 सितंबर 2007 dead NALP-1 RERE, PTPN22, LPP, IL2RA, GZMB, UBASH3A and C1QTNF6 Wegener's granulomatosis AcceptedSánchez-Cano D, Callejas-Rubio JL, Ortego-Centeno N Effect of rituximab on refractory Wegener granulomatosis with predominant granulomatous disease J Clin Rheumatol 14 2 92–3 2008 April 18391678 10.1097/RHU.0b013e31816b4487 http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00124743-200804000-00008 1 जुलाई 2012 https://web.archive.org/web/20120311155242/http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00124743-200804000-00008 11 मार्च 2012 live Anti-neutrophil cytoplasmic(cANCA) चिकित्सा-विकास इन्हें भी देखें स्वरोगक्षमता या स्वप्रतिरक्षा (Autoimmunity) प्रतिरक्षा विज्ञान (Immunology) प्रतिरक्षा प्रणाली (Immune System) अन्य पठनीय सामग्री Vinay Kumar, Abul K. Abbas, Nelson Fausto, Jon Aster, Robbins and Cotran Pathologic Basis of Disease, Elsevier, 8th edition, 2010, 1464 pp., ISBN 978-1-4160-3121-5 Handbook of Systemic Autoimmune Diseases, edited by Ronald Asherson, Elsevier, in 10 Volumes : Ronald Asherson, Andrea Doria, Paolo Pauletto, The Heart in Systemic Autoimmune Diseases, Volume 1, 2004, ISBN 978-0-444-51398-4, ISBN 0-444-51398-1 Ronald Asherson, Andrea Doria, Paolo Pauletto, Pulmonary Involvement in Systemic Autoimmune Diseases, Volume 2, 2005, ISBN 978-0-444-51652-7, ISBN 0-444-51652-2 Ronald Asherson, Doruk Erkan, Steven Levine, The Neurologic Involvement in Systemic Autoimmune Diseases, Volume 3, 2005, ISBN 978-0-444-51651-0, ISBN 0-444-51651-4 Michael Lockshin, Ware Branch (eds), Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases, Volume 4, 2006, ISBN 978-0-444-51801-9, ISBN 0-444-51801-0 Piercarlo Sarzi-Puttini, Ronald Asherson, Andrea Doria, Annegret Kuhn, Giampietro Girolomoni (eds), The Skin in Systemic Autoimmune Diseases, Volume Volume 5, 2006, ISBN 978-0-444-52158-3, ISBN 0-444-52158-5 Rolando Cimaz, Ronald Asherson, Thomas Lehman (eds), Pediatrics in Systemic Autoimmune Diseases, Volume 6, 2008, ISBN 978-0-444-52971-8, ISBN 0-444-52971-3 Justin Mason, Ronald Asherson, Charles Pusey (eds), The Kidney in Systemic Autoimmune Diseases, Volume 7, 2008, ISBN 978-0-444-52972-5, ISBN 0-444-52972-1 Ronald Asherson, Manel Ramos-Casals, Joan Rodes, Josep Font, Digestive Involvement in Systemic Autoimmune Diseases, Volume 8, 2008, ISBN 978-0-444-53168-1, ISBN 0-444-53168-8 Ronald Asherson, Sara Walker, Luis Jara, Endocrine Manifestations of Systemic Autoimmune Diseases, Volume 9, 2008, ISBN 978-0-444-53172-8, ISBN 0-444-53172-6 R. Cervera, Ronald Asherson, Munther Khamashta, Joan Carles Reverter (eds), Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Volume 10, 2009, ISBN 978-0-444-53169-8, ISBN 0-444-53169-6 सन्दर्भ 2 इन्हें भी देखें प्रतिरक्षा प्रणाली (immune system) स्वरोगक्षमता (autoimmunity) बाहरी कड़ियाँ