JAKinib

jakinib English Alternative forms en jakinib Etymology From en JAK Janus kinase -in- -ib small molecule inhibitor. Noun en pharmacology A Janus kinase inhibitor. en 2019-07-08 Michael Bonelli; Karolina Dalwigk; Alexander Platzer; Isabel Olmos Calvo; Silvia Hayer; Birgit Niederreiter; et al. IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes w:Experimental & Molecular Medicine 51 10.1038/s12276-019-0267-6 1 Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs.