ICK

ick Ick -ick English Noun en biochemistry en w:inhibitor cystine knot. en 2022-06-10 Oliveira, A.L., Viegas, M.F., da Silva, S.L. et al. The chemistry of snake venom and its medicinal potential w:Nature Reviews Chemistry 6 10.1038/s41570-022-00393-7 451 https://www.nature.com/articles/s41570-022-00393-7 The composition of the venoms of the first three is dominated by short (3–9-kDa) disulfide-rich peptides that contain the inhibitor cysteine knot (ICK) motif, although heavier proteins, including enzymes, are also present. ICK peptides are structurally very stable and mainly target the nervous system, acting primarily on membrane channels or neuronal receptors3,4,5. https://web.archive.org/web/20241207013946/https://www.nature.com/articles/s41570-022-00393-7 7 December 2024