FLS

English Noun ~ en Frontline State. en cytology en w:fibroblast-like synoviocyte. en 2019-07-08 Michael Bonelli; Karolina Dalwigk; Alexander Platzer; Isabel Olmos Calvo; Silvia Hayer; Birgit Niederreiter; et al. IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes w:Experimental & Molecular Medicine 51 10.1038/s12276-019-0267-6 1 The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory mediators. Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis mouse model.