Jennifer Doudna

Jennifer Doudna Jennifer Anne Doudna (born February 19, 1964) is an American biochemist. She shared the 2020 Nobel Prize in Chemistry with Emmanuelle Charpentier for their pioneering research in CRISPR gene editing. Quotes I had this impression from the media that science was for old white guys, people who looked like Einstein, that it wasn’t for people like me ... as quoted by Joel Achenbach, https://www.washingtonpost.com/national/health-science/pondering-what-it-means-to-be-human-on-the-frontier-of-gene-editing/2016/05/03/a639b3ae-0bbb-11e6-bfa1-4efa856caf2a_story.html Pondering 'what it means to be human' on the frontier of gene editing May 3, 2016 The Washington Post ... CRISPR is, in fact, a bacterial immune system. It’s an ancient system that evolved in microbes to allow prevention of viral infection. Our interest in this started with that fundamental biology, asking, “How does this work?” We did a collaborative research project with Emmanuelle Charpentier, a medical microbiologist, and our work with her laboratory revealed that one of the components of this CRISPR immune system is, in fact, a protein that’s called Cas9, that can be programmed to find and cut virus DNA.We published this work back in the summer of 2012, and for me, life hasn't been the same since. https://www.mckinsey.com/industries/life-sciences/our-insights/programming-life-an-interview-with-jennifer-doudna Programming life: An interview with Jennifer Doudna McKinsey & Company June 4, 2020 (interview by McKinsey & Company McKinsey partner Michael Chui) ... I just think you have to embrace your passions. You have to really go for it. People that have been less successful, in my opinion, are those that dabble in something, but then don’t really give it their all. They almost never give themselves a chance to succeed, as they back off too soon. I think for young people, I tell them go for it, find supportive mentors who will help you through the tough times, and then just keep going. Because if you have a good idea, it’s probably going to work out in some way. You may not be able to predict how, but you should just keep pursuing it. https://www.nobelprize.org/prizes/chemistry/2020/doudna/167713-jennifer-doudna-interview-february-2021/ Interview with Jennifer A. Doudna, February 2021 The Nobel Prize in Chemistry 2020 (nobelprize.org) When I was taught biology, we learned about the structure and code of DNA, and we learned about how proteins do all the heavy lifting in cells, and RNA was treated as this dull intermediary, sort of a middle manager ... I was quite surprised that there was this young genius, Jack Szostak, at Harvard who wanted to focus a hundred percent on RNA because he thought that it was the key to understanding the origin of life. as quoted by Walter Isaacson, https://books.google.com/books?id=f_D3DwAAQBAJ&pg=PA45 45 The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race 9781982115876 2021 Simon and Schuster ... it's kind of a catchy acronym. It stands for Clusters of Regularly Interspaced Short Palindromic Repeats. Oh! Don't make me say that again. ... What it means — what it symbolizes — is an immune system in bacteria that uses sequences of DNA (that come originally from viruses) ... that are transcribed into molecules of RNA that can use a search-and-destroy mechanism in cells to find and cut up virus genetic material https://www.youtube.com/watch?v=PYjgLHfvvmU&t=350s The Code Breaker: A Conversation with Jennifer Doudna March 29, 2022 Whitehead Institute for Biomedical Research, YouTube (interview by Ruth Lehmann) (quote at 5:50 of 49:15 in video) Two years ago, I was working on my laptop in an airport lounge in Newark, New Jersey, when I glanced up and saw a couple walking with their two boys. The younger boy slowly made his way on crutches, displaying the telltale signs of a hereditary disease called muscular dystrophy. Generally manifesting in childhood, the disease steadily robs those who have it of their ability to walk. Eventually, I knew, the crutches would no longer be enough.My heart skipped a beat. Most types of muscular dystrophy originate with genetic mutations that weaken key muscle proteins, and I had just come from a meeting where a cure appeared possible, using CRISPR technology to rewrite the DNA of kids just like him.Imagining how the technology I’d helped create could change this boy’s life, I was overwhelmed with emotion. Beyond hope and wonder, I was filled with a sense of fierce urgency to expand CRISPR’s impact to the people around the world who need it most. Starting a Revolution Isn’t Enough: CRISPR is changing the world—but it can do more. The Atlantic September 12, 2022 https://www.theatlantic.com/science/archive/2022/09/crispr-cas9-gene-editing-biotechnology/671382/ External links Category:1964 births Category:Living people Category:Women academics from the United States Category:Biologists from the United States Category:Chemists from the United States Category:Geneticists Category:Nobel laureates from the United States Category:Wolf Prize in Medicine laureates Category:Women Nobel laureates Category:Women scientists from the United States Category:Women born in the 1960s