Errol Friedberg

Errol Clive Friedberg (born October 2, 1937) is an American molecular biologist and historian of science, elected a Fellow of the American Association for the Advancement of Science in 2007. Quotes Living cells respond to DNA damage by a variety of mechanisms, including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases, called base excision repair, mismatch repair and nucleotide excision repair (NER).NER in human cells is a complex biochemical process during which a large multiprotein complex is assembled at several types of base damage. This multiprotein complex (NER machine) catalyses the excision of damaged bases as oligonucleotide fragments. How nucleotide excision repair protects against cancer Nature Reviews Cancer 1 1 2001 22–33 1474-175X 10.1038/35094000 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution. DNA damage and repair Nature 421 6921 2003 436–440 0028-0836 10.1038/nature01408 Because of the questions posed by Schrödinger and the nature of the problem of identifying and describing the gene itself, the early development of molecular biology relied greatly on scientists who brought insights from physics to biology—Max Delbrück, Salvador Luria, George Gamow, Sir Lawrence Bragg, Francis Crick, Max Perutz, John Kendrew, Maurice Wilkins, Desmond Bernal, and Linus Pauling being the best known of these scientists. The Writing Life of James D. Watson https://books.google.com/books?id=WR1GcZAR6RQC&pg=PA10 2005 CSHL Press 978-0-87969-700-6 10 External links Category:1937 births Category:Living people Category:Academics from the United States Category:Biologists from the United States Category:Geneticists Category:Historians of science Category:Historians from the United States