Radiation Oncology/RTOG Trials/7605

RTOG 76-05 (LIVER) Title: Pilot Study of Radiotherapy for Palliation of Symptomatic Hepatic Metastases Objective: I. Evaluate the frequency and duration of symptom relief, frequency and duration of normalization of (a) liver tests and (b) of abnormal liver scans, as a function of dose schedules, varying fraction size and overall time. II. Evaluate the above responses according to site and histopathology of the primary. III. Evaluate the above objectives with respect to survival times. IV. Evaluate, via histopathologic correlation, the frequency of radiation hepatitis as a function of dose schedule and concomitant chemotherapy. Protocol: RT for patients with solitary vs. multiple mets Eligibility: hepatic metastases documented by liver scan Enrolled: Conclusion: 6168623 -- The palliation of hepatic metastases: results of the Radiation Therapy Oncology Group pilot study. (1981 Borgelt BB, Int J Radiat Oncol Biol Phys. 1981 May;7(5):587-91.) Publications: 2180867 -- Accelerated fractionation radiation therapy for liver metastases: selection of an optimal patient population for the evaluation of late hepatic injury in RTOG studies. (1990 Leibel SA, Int J Radiat Oncol Biol Phys. 1990 Mar;18(3):523-8.)