Radiation Oncology/Cancer Syndromes/Nijmegen Breakage Syndrome-Like Disorder

Nijmegen Breakage Syndrome-Like Disorder DNA Repair chapter Low levels of unstable RAD50 protein; part of MRN complex involved in DNA double-strand break recognition and repair Microcephaly, mental retardation, "bird-like" face, short stature 1 individual reported to-date Sensitivity to ionizing radiation Hannover; 2009 19409520 -- "Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder." (Waltes R, Am J Hum Genet. 2009 May; 84(5):605-16.) Case report of patient with NBSLD