Structural Biochemistry/Membrane Proteins/Ion Channels/Transient receptor potential channel

Transient receptor potential (TRP) ion channels get their name from a Drosophila phototransduction mutant that show a transient instead of a sustained response to bright light. In addition to responses to light, TRPs mediate responses to nerve growth factor, pheromones, olfaction, mechanical, chemical, temperature, pH, osmolarity, vasorelaxation of blood vessels, and metabolic stress. TRP-related ion channel proteins are found in a variety of organisms, tissues, and cell types, including nonexcitable, smooth muscle, and neuronal cells. TRP channels are recruited to diverse signaling pathways, such as gating mechanisms, regulation, and permeability. Reference: 1. Ajay Dhaka, Veena Viswanath, and Ardem Patapoutian, "TRP Ion channels and Temperature Sensation" 2. Baruch Minke and Boaz Cook, "TRP Channel Proteins and Signal Transduction" 3. Kartik Venkatachalam and Craig Montell, "TRP Channels" 4.http://en.wikipedia.org/wiki/Transient_receptor_potential_channel 5.CHEN jingyu, MENG Hui, FENG Hua, "TRP channel and central nervous system diseases" 6.HAN ChongYang, WANG XiaoLiang, "Recent Advances on TRP Channels"