Radiation Oncology/CNS/Introduction

Survival 2-year and 5-year OS of various primary CNS tumors: Astrocytoma, Pilocytic WHO grade I - 90% Astrocytoma WHO grade II - 66% Astrocytoma WHO grade III - 45% and 34% GBM - 9% Oligodendroglioma - 81% and 65% Medulloblastoma - 66% and 60% Ependymoma - 83% and 60% Tumors that might be irradiated without pathologic diagnosis Optic glioma Diffuse pontine glioma Meningioma Choroidal melanoma CNS tumors that are most likely to metastasize outside the CNS Glioblastoma Medulloblastoma Ependymoma Hemangiopericytoma Meningioma Pathologic correlations Rosenthal fibers - JPA Psammoma bodies - meningioma (and papillary tumors such as thyroid or endometrial) Verocay bodies - schwannoma Schiller Duval body - yolk sac tumor Fried egg appearance - oligodendroglioma Pseudorosettes (central lumen not formed by the growth itself, unlike a rosette) - ependymoma, but also PNET, medulloblastoma Homer-Wright rosette - PNET, medulloblastoma, pineoblastoma, neuroblastoma Flexner-Wintersteiner rosette - retinoblastoma