Structural Biochemistry/Intrinsically Disordered Proteins: 10-year recap/Introduction

Introduction More than 10 years ago, the general consensus for the theory of how various proteins have different functions was that structure determines function. However, this is not always the case by the discovery of parts of proteins that are intrinsically disordered. The proposition that the original and native state of the vast variety of proteins is intrinsically disordered (unstructured) is a concept that many scientists take into account to their general view of protein structure and function. Years and years of new discoveries and insightful knowledge led to the importance of intrinsically disordered regions on proteins for certain functions. Reference 10.1016/j.tibs.2012.08.004 22989858 Intrinsically disordered proteins: A 10-year recap Trends in Biochemical Sciences 37 12 509–16 2012 Tompa Peter