Structural Biochemistry/Adalat

Overview Adalat is drugs with generic name nifedipine produced by Bayer and is classified as a calcium channel blocker. It has the chemical name 3,5-pyridinedicarboxylic acid, 1,4-dihydro=2,6=dimethyl-4=(2=nitrophenyl I)-dimethyl ester. The drug is often prescribed to treat hypertension. The drug is available in tablet form and has a bioavailability of 84-89 percent after oral administration. Nifedipine is metabolized via the cytochrome P450 3A4 system, located both in the intestinal mucosa and in the liver with a half life of 2 hours. The drug is 1,4 dihydropyridine calcium channel blocker and is a selective vasodilator. Normally in the heart, heart rate is increased by calcium ions binding to calcium channels within the heart. The increased heart rate causes vasoconstriction in the arteries by shrinking the artery wall. What the drug does is actually block calcium from interacting with the calcium channels within the heart and this allows the artery walls to dilate to prevent hypertension while the heart slows down. Some of the extreme side effects include hypotension, arrhythmias, and congestive heart failure. It is also important to not have grape fruit with this drug. Side Effects Contact a doctor if you present one or more of the following symptoms after taking adalat: hives difficulty breathing swelling of lips, face, throat or tongue worsening angina feel like passing out short of breath swelling on your limbs fast heartbeat pounding numbness jaundice (yellow skin or eyes) chest pain or heavy feeling Less serious side effects include: headache dizziness drowsiness constipation nausea diarrhea stomach pain insomnia rash or itching joint pain more urination than usual Incompatibility with other drugs Adalat might produce severe reactions if mixed with one or more of the following medications: acarbose cimetidine fentanyl or other narcotic pain medications digoxin nefazodone St. John's wort rifabutin blood thinner anti-fungal medication beta-blocker heart rhythm medication HIV/AIDS medication seizure medication References http://www.drugs.com/adalat.html http://www.medterms.com/script/main/art.asp?articlekey=3846 http://www.rxlist.com/adalat-drug.htm https://online.epocrates.com http://online.factsandcomparisons.com