Gynecologic Oncology/Cervical Cancer

Chemotherapy for advanced and recurrent disease Bonomi et al (GOG 43) 3894589 Compared three regimens of cisplatin dosing Regimen 1: 50 mg/m2 every 21 days Regimen 2: 100 mg/m2 every 21 days Regimen 3: 20 mg/m2 for five consecutive days repeated every 21 days Differences in overall response rates were higher for regimen 2 (SS), but the PFS/OS/Complete response rates were virtually identical (NS) Established 50 mg/m2 as the preferred regimen due to lower toxicity and ease (regimen 3 had multiple hospital visits) +RegimenNumberPFSOSResponse Rate (RR)11503.77.120.7%21664.6731.4%31283.96.125 %