Radiation Oncology/Pancreatic Endocrine Neoplasm

Pancreatic Endocrine Neoplasms (PEN) Uncommon tumors, incidence ~4/1,000,000 Can be either functional or nonfunctional; common functional tumors include insulinoma and gastrinoma (giving rise to Zollinger-Ellison Syndrome (ZES)) European Neuroendocrine Society suggests TNM staging and grade are predictive of tumor behavior Treatment for localized PENs is surgical resection or enucleation Lymph node status important prognostic factor, so LND should be considered, especially since tumor size does not correlate with LN status Low grade tumors have excellent long-term outcomes, 5-year OS >90% Intermediate grade tumors with LN+ or DM+ have 5-year OS ~58%