Radiation Oncology/RTOG Trials/9019

RTOG 90-19 (PROSTATE) Link to textbook This is a SWOG-8794 Study (INT-0086, CALGB-9493, EST-9887) Title: A Phase III Study of the Treatment of Pathologic Stage C Carcinoma of the Prostate With Adjuvant Radiotherapy Objectives: (1) To compare the disease-free survival rates in completely resected patients with pathologic stage C (T3N0M0) carcinoma of the prostate assigned to be treated with adjuvant external beam radiotherapy to that in patients assigned to receive no adjuvant therapy (2) To assess the qualitative and quantitative toxicities of patients with pathologic stage C (T3N0M0) carcinoma of the prostate when treated with external beam radiotherapy. Protocol: Arm 1: Radical Prostatectomy Arm 2: Radical Prostatectomy + 60-64 Gy EBRT Eligibility: Status Post RP, +ECE or +SVI or +SM, N0M0 Activation: August 15, 1988 (RTOG Activation: April 20, 1992) Closed: January 1, 1997 Publications: 2007 17538167 -- "Predominant treatment failure in postprostatectomy patients is local: analysis of patterns of treatment failure in SWOG 8794." (Swanson GP, J Clin Oncol. 2007 Jun 1;25(16):2225-9.) Conclusion: Failure in high risk patients predominately local; adjuvant RT reduces risk of failure 2006 17105795 — "Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial." (Thompson IM Jr et al. JAMA. 2006 Nov 15;296(19):2329-35.) Conclusion: Adjuvant radiotherapy resulted in significantly reduced risk of PSA relapse and disease recurrence, although the improvements in metastasis-free survival and overall survival were not statistically significant. 2005 ASTRO Abstract Plenary #1, 2005 Webcast - "Phase III Randomized Study of Adjuvant Radiation Therapy versus Observation in Patients with Pathologic T3 Prostate Cancer (SWOG 8794)" Swanson GP et al. IJROBP Volume 63, Supplement 1 , 1 October 2005, Page S1. 1994 No Abstract -- "An opportunity to determine optimal treatment of pT3 prostate cancer: the window may be closing." (Thompson IM, Urology 1994). Review 1992 -- "Adjuvant Radiotherapy Following Radical Prostatectomy for Pathologic Stage C Adenocarcinoma of the Prostate: Initial Evaluation of Toxicity." I Thompson, ED Crawford, G Miller, J Paradelo, B Blumenstein, M Wolf, C Moinpour, K Hayden. American Society of Clinical Oncology 11:212 (#663), 1992.