Radiation Oncology/CNS/RTOG Brain

RTOG Website Wikibooks list of RTOG trials +Brain/CNS: RTOG OPEN TRIALS NumberSiteTitle 08-37 GBM Randomized, Phase II, Double-Blind, Placebo-Controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Cediranib Versus Conventional Chemoradiation and Adjuvant Temozolomide Plus Placebo in Patients With Newly Diagnosed Glioblastoma 08-34 Anaplastic Glioma Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma: The CATNON Intergroup Trial 08-25 GBM PHASE III DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF CONVENTIONAL CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE PLUS BEVACIZUMAB VERSUS CONVENTIONAL CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA 06-27 GBM (recur.) Phase II Trial of Dasatinib in Patients With Recurrent Glioblastoma Multiforme 06-25 GBM (recur.) A RANDOMIZED PHASE II TRIAL OF BEVACIZUMAB WITH IRINOTECAN OR BEVACIZUMAB WITH TEMOZOLOMIDE IN RECURRENT GLIOBLASTOMA 06-14 WBRT A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy 06-11 GBM Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence 05-39 Meningioma Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas 05-25 GBM Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients With Newly Diagnosed Glioblastoma 03-20 Cancer.gov Mets A PHASE III TRIAL COMPARING WHOLE BRAIN RADIATION AND STEREOTACTIC RADIOSURGERY ALONE VERSUS WITH TEMOZOLOMIDE OR ERLOTINIB IN PATIENTS WITH NON-SMALL LUNG CANCER AND 1-3 BRAIN METASTASES 02-27 Cancer.gov PCNSL Phase I/II Study of Pre-Irradiation Chemotherapy With Methotrexate, Rituximab, and Temozolomide and Post-Irradiation Temozolomide for Primary Central Nervous System Lymphoma 98-13 Cancer.gov AA and AOA A Phase I/III Randomized Study Of Radiation Therapy And Temozolomide (IND #60,265) Versus Radiation Therapy And Nitrosourea For Anaplastic Astrocytoma and Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant) 15234047 (phase I) 98-06 GBM A Phase II Study of Conventional Radiation Therapy Plus Thalidomide For Supratentorial Glioblastoma +Brain/CNS: RTOG CLOSED TRIALSNumber Site Title Publication 05-13 Cancer.gov GBM A Phase I/II Trial of Temozolomide, Motexafin Gadolinium, and 60 Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme Closed 7/1/2009 04-24 Cancer.gov LGG A Phase II Study of Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas Closed 10/31/2009 04-20 Cancer.gov GBM A PHASE II STUDY OF RADIATION THERAPY PLUS LOW DOSE TEMOZOLOMIDE FOLLOWED BY TEMOZOLOMIDE PLUS IRINOTECAN FOR GLIOBLASTOMA MULTIFORME ASCO 2006 02-11 Cancer.gov GBM A PHASE I/II STUDY OF AN ORAL EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR (EGFR-TKI), ZD 1839 (IRESSA), [NSC# 715055] WITH RADIATION THERAPY IN GLIOBLASTOMA MULTIFORME ASCO 2004ASCO 2006 01-31 Clinicaltrials.gov Glioma: AO and Mixed AOA A Phase II Trial of Pre-Irradiation and Concurrent Temozolomide in Patients with Newly Diagnosed Anaplastic Oligodendrogliomas and Mixed Anaplastic Oligoastrocytomas 18779504 01-18 Clinicaltrials.gov Mets A Phase III Study of Conventional Radiation Therapy Plus Thalidomide (NSC# 66847) Versus Conventional Radiation Therapy for Multiple Brain Metastases 18164847 18164829 00-23 Clinicaltrials.gov GBM A Phase II Trial of Accelerated Radiotherapy Using Weekly Stereotactic Conformal Boosts For Supratentorial Glioblastoma Multiforme 16750317 00-21 GBM A Phase II Trial Of Conventional Radiation Therapy Plus High Dose Tamoxifen For The Treatment Of Supratentorial Glioblastoma Multiforme 16443947 98-13 AA 15234047 98-06 Glioma [Phase II, RT + Thalidomide] 98-03 GBM Phase I/II Radiation Dose Escalation Study Applying Conformal Radiation Therapy In Supratentorial Glioblastoma Multiforme 19533025 (QOL) 18723297 98-02 Clinicaltrials.gov LGG A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase III Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma 18976072 97-10 GBM A phase II study of conventional radiation therapy followed with recombinant interferon beta for supratentorial glioblastoma ASTRO 2001 16887285 96-02 Glioma [Phase II, RT + Taxol] 95-08 Cancer.gov Mets A PHASE III TRIAL COMPARING WHOLE BRAIN IRRADIATION WITH VERSUS WITHOUT STEREOTACTIC RADIOSURGERY BOOST FOR PATIENTS WITH ONE TO THREE UNRESECTED BRAIN METASTASES 15158627 95-07 GBM Phase I Study of Topotecan plus Cranial Radiotherapy for Glioblastoma Multiforme 11181676 94-04 AA 15001257 94-02 Clinicaltrials.gov AO Phase III intergroup randomized comparison of radiation alone vs pre-radiation chemotherapy for pure and mixed anaplastic oligodendrogliomas 11586105 16782910 18371182 19783377 (QOL) 93-10 PCNSL 16193393 93-05 Glioma [+/- SRS then RT + BCNU] 91-13 HGG (Recur.) 9210068 91-10 LGG A phase III evaluation of postoperative radiation in low grade intracranial astrocytomas and oligodendrogliomas 11980997 12829670 (Cognitive) 15964709 (Cognitive) 90-06 Glioma [BCNU + (HF-RT vs RT)] 90-05 Mets [Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases] 8621289 10802351 85-28 Mets [Phase I/II trial of accelerated fractionation in brain metastases] 8330997 8435812 84-09 Glioma [Phase I/II WBRT + AZQ] 83-02 HGG [Phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas] 1451073 8380567 8608540 more.. 79-18 Glioma [WBRT + (BCNU vs Misonidazole + BCNU)] 74-01 HGG [WBRT 60 Gy vs 60 Gy + 10 Gy boost vs 60 Gy + BCNU vs 60 Gy + BCNU + dacarbazine] 3281031 Note: Titles are given in brackets when the official protocol title is not known