Chemical Sciences: A Manual for CSIR-UGC National Eligibility Test for Lectureship and JRF/Capillary electrophoresis-mass spectrometry

Capillary electrophoresis mass spectrometry (CEMS) is an analytical chemistry technique formed by the combination of the liquid separation process of capillary electrophoresis with mass spectrometry.Loo JA, Udseth HR, Smith RD Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry Anal. Biochem. 179 2 404–12 1989 June 2774189 10.1016/0003-2697(89)90153-X Ions are typically formed by electrospray ionization,Maxwell EJ, Chen DD Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry Anal. Chim. Acta 627 1 25–33 2008 October 18790125 10.1016/j.aca.2008.06.034 http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(08)01244-0 but they can also be formed by matrix-assisted laser desorption ionizationZhang H, Caprioli RM Capillary electrophoresis combined with matrix-assisted laser desorption/ionization mass spectrometry; continuous sample deposition on a matrix-precoated membrane target J Mass Spectrom 31 9 1039–46 1996 September 8831154 10.1002/(SICI)1096-9888(199609)31:9<1039::AID-JMS398>3.0.CO;2-F or other ionization techniques. It has applications in basic research in proteomicsMetzger J, Schanstra JP, Mischak H Capillary electrophoresis-mass spectrometry in urinary proteome analysis: current applications and future developments Anal Bioanal Chem 393 5 1431–42 2008 August 18704377 10.1007/s00216-008-2309-0 and quantitative analysis of biomoleculesOhnesorge J, Neusüss C, Wätzig H Quantitation in capillary electrophoresis-mass spectrometry Electrophoresis 26 21 3973–87 2005 November 16252322 10.1002/elps.200500398 as well as in clinical medicine.Kolch W, Neusüss C, Pelzing M, Mischak H Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery Mass Spectrom Rev 24 6 959–77 2005 15747373 10.1002/mas.20051Dakna M, He Z, Yu WC, Mischak H, Kolch W Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877 13 1250–8 2008 November 19010091 10.1016/j.jchromb.2008.10.048 http://linkinghub.elsevier.com/retrieve/pii/S1570-0232(08)00801-5 References