411 REFERENCE · Wikibooks
Chess Opening Theory/1. e4/1...c5/2. Nf3/2...d6/3. Nc3
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3. Nc3 is a flexible choice, which leaves Black with the decision making process. White can still go for the Open Sicilian with d4 break, or a closed setup with g3, or something like the canal attack or rossolimo with Bb5.