Radiation Oncology/GOG

Gynecologic Oncology Group (GOG) Gynecologic Oncology Group website Wikipedia GOG page Wikibooks Endometrial cancer page 88XX-02XX GOG 0230-C - Uterus/Carcinosarcoma - A Phase II Evaluation of GLEEVEC (NCI-Supplied Agent: STI571 [Imatinib Mesylate], IND#61135, NSC#716051) in the Treatment of Recurrent or Persistent Carcinosarcoma of the Uterus GOG 0227-C - Cervix - A Phase II Evaluation of Bevacizumab (rhuMAB VEGF) (NSC# 704865 IND#7921) in the Treatment of Persistent or Recurrent Squamous Cell Carcinoma of the Cervix GOG 0210 - Endometrium - A Molecular Staging Study of Endometrial Carcinoma GOG 0209 - Endometrium - Randomized Phase III Trial of Doxorubicin/Cisplatin/Paclitaxel and G-CSF Versus Carboplatin/Paclitaxel in Patients with Stage III & IV or Recurrent Endometrial Cancer GOG 0199 - Ovary - Prospective Study of Risk-Reducing Salpingo-Oophorectomy and Longitudinal CA-125 Screening Among Women at Increased Risk of Ovarian Cancer GOG 0184 - Endometrium - A Randomized Phase III Study of Tumor Volume directed Pelvic Plus or Minus Para-Aortic Irradiation Followed by Cisplatin and Doxorubicin or Cisplatin, Doxorubicin and Paclitaxel for Advanced Endometrial Carcinoma GOG 0182 - Ovary - A Phase III Randomized Trial of Paclitaxel and Carboplatin Versus Triplet or Sequential Doublet Combinations in Patients With Epithelial Ovarian or Primary Carcinoma. GOG 0181-B - Endometrium - A Phase II Evaluation of Trastuzumab (MoAb HER 2) in Patients with Recurrent or Advanced Endometrial Carcinoma GOG 9908 - Endometrium - Sequential chemotherapy and irradiation in advanced stage endometrial cancer: A Gynecologic Oncology Group phase I trial of doxorubicin-cisplatin followed by whole abdomen irradiation. 19135232 (2009) GOG 9907 - Endometrium - Phase I trial of the treatment of high-risk endometrial cancer with concurrent weekly paclitaxel and cisplatin and whole abdominal radiation therapy 18962846 (2009) GOG 9804 - Cervix - Phase I/II study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes 19010522 (2009) GOG 9404 - Ovary - P53 MUTATION AND C-ERB B-2 EXRESSION IN ADVANCED STAGE EPITHELIAL OVARIAN CARCINOMA AND CORRELATION WITH PROGNOSTIC FACTORS AND TREATMENT OUTCOME GOG 9303 - Ovary - CISPLATIN-DNA ADDUCTS IN OVARIAN CANCER AS A PREDICTOR OF RESPONSE TO PLATINUM-BASED CHEMOTHERAPY GOG 9203 - Ovary - Phase I trial of paclitaxel and etoposide for recurrent ovarian carcinoma 11202808 (2000) GOG 9001 (1990-92) - Endometrial - A phase I study of weekly cisplatin and whole abdominal radiation for the treatment of stage III and IV endometrial carcinoma: a Gynecologic Oncology Group pilot study. 8946862 (1996) GOG 8809 - Ovary - FLOW CYTOMETRICALLY DETERMINED TUMOR DNA CONTENT IN OVARIAN TUMOR OF LOW MALIGANT POTENTIAL 201-300 GOG 258 (ongoing) - Endometrium - A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma GOG 206 (ongoing, 2003-) - Cervix - Stage IB1. Sentinal lymph node biopsy. GOG 205 (2005-2009) - Vulva - Phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva. Unresectable, T3-T4 any N. RT + weekly cisplatin followed by resection of residual tumor. GOG 204 - Cervix - Advanced. Rand to 4 cisplatin doublets (taxol, vinorelbine, gemcitabine, or topotecan) 19720909 (2009) 151-200 GOG 191 - Cervix - Stage III. Chemo-RT +/- EPO chapter link 18037478 (2008): Stopped prematurely due to concerns about thromboembolism GOG 185 - Vulva - Phase III randomized study of adjuvant radiation treatment versus radiation and chemotherapy (cisplatin) in patients with vulvar cancer and involved nodes GOG 184 - Endometrium - A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin or with or without paclitaxel 19108877 (2009) GOG 0177 - Endometrium - Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma 15169803 (2004), HER2-neu: 17945336 (2008) GOG 175 - Ovary - A Randomized Phase III Trial Of IV Carboplatin (AUC 6) and Paclitaxel 175 MG/M2 Q 21 Days X 3 Courses Plus Low-Dose Paclitaxel 40 MG/M2 Weekly VS. Carboplatin (AUC 6) and Paclitaxel 175MG/M2 Q21 Days X 3 Courses in Patients With Early Stage Ovarian Cancer GOG 173 - Vulva - Sentinal lymph node mapping (Stage I-II) ASCO 2009 Abstract #5505 GOG 172 - Ovary - A PHASE III RANDOMIZED TRIAL OF INTRAVENOUS PACLITAXEL AND CISPLATIN VERSUS INTRAVENOUS PACLITAXEL, INTRAPERITONEAL CISPLATIN AND INTRAPERITONEAL PACLITAXEL IN PATEINTS WITH OPTIMAL STAGE III EPITHELIAL OVARIAN CARCINOMA OR PRIMARY PERITONEAL CA GOG 171 - Cervix - Expression of the MN Protein in Atypical Glandular Cells of Undetermined Significance (AGUS or AGCUS) as a Potential Diagnostic Biomarker of Cervical Dysplasia/Neoplasia GOG 165 - Cervix - A RANDOMIZED COMPARISON of RADIATION PLUS WEEKLY CISPLATIN VS RADIATION PLUS PVI (PROTECTED VENOUS INFUSION) 5-FU IN PATIENTS WITH STAGE II-B, III-B, AND IVA CARCINOMA OF THE CERVIX 16230678 (2005) GOG 163 - Endometrium - A Randomized Study of Doxorubicin + Cisplatin vs. Doxorubicin + 24 HOUR Paclitaxel + G-CSF In Patients With Primary Stage III & IV Or Recurrent Endometrial Carcinoma GOG 161 - Uterus/Mixed Mesodermal - A Phase III Trial of Ifosfamide vs Ifosfamide Plus Paclitaxel in Patients with Advanced, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumor) of the Uterus 17290061 (2007) GOG 159 - Endometrium - A PHASE II STUDY OF GOSERELIN ACETATE (ZOLADEX) IN RECURRENT OR PERSISTENT ENDOMETRIAL CANCER GOG 158 - Ovary - A Phase III Randomized Study Of Cisplatin & Paclitaxel (24 Hour Infusion) Versus Carboplatin & Paclitaxel (3-Hour Infusion) In Optimal Stage III Epithelial Ovarian Carcinoma GOG 157 - Ovary - A Randomized Phase III Trial Of Carboplatin (AUC 7.5) & Paclitaxel 175 Mg/M Q 21D X 3 Courses vs. Same Regimen X 6 Courses In Patients With Selected Stage IC And II II (A,B,C) And Selected IA AND IB Ovarian Cancer. GOG 156 - Endometrium - Stage IB and IIB, Surgery + Pelvic RT vs. Surgery + Adriamycin/Cisplatin Closed due to nonaccrual GOG 154 - Cervix - HUMAN IMMUNODEFICIENCY VIRUS (HIV) TESTING IN PATIENTS WITH INVASIVE CERVICAL CANCER 101-150 GOG 150 - Uterus/Carcinosarcoma - adjuvant WAI vs. CIM. No statistically significant advantage of one over the other. Pelvic recurrences reduced with RT 17822748 (2007) GOG 149 - Cervix - A RANDOMIZED STUDY OF CISPLATIN PLUS IFOSFAMIDE & MESNA VS CISPLATIN, BLEOMYCIN,IFOSFAMIDE & MESNA IN STAGE IVB RECURRENT OR PERSISTENT SQUAMOUS CELL CARCINOMA OF THE CERVIX GOG 146-H - Ovary - EVALUATION OF PYRAZOLOACRIDINE (PZA) IN RECURRENT,PLATINUM SENSITIVE OVARIAN CANCER GOG 146-F - Ovary - EVALUATION OF 24-HOUR CONTINUOUS INFUSION OF TOPOTECAN IN RECURRENT AND PLATINUM-SENSITIVE OR METASTATIC OVARIAN CANCER GOG 146D - Ovary - EVALUATION OF PYRAZOLOACRIDINE (PZA) IN RECURRENT PLATINUM SENSITIVE OVARIAN CANCER GOG 145 - Vulva - Randomized study of adjuvant treatment including radiation therapy and chemotherapy in patients with vulvar cancer GOG 141 - Cervix - Neoadjuvant chemo followed by rad hyst vs rad hyst alone. Closed early. GOG 0136 - Other - Acquisition of Human Gynecologic Specimens and Serum to be Used in Studying the Causes, Diagnosis, Prevention and Treatment of Cancer GOG 132 - Ovary - Phase III randomized study of cisplatin versus paclitaxel versus cisplatin and paclitaxel in patients with suboptimal stage III or IV ovarian cancer 10623700 (2000) GOG 129-G - Endometrium - EVALUATION OF 9-CIS RETINOIC ACID(9-CRA, NSC#659722) IN THE TREATMENT OF REFURRENT OR PERSISTENT ENDOMETRIAL CARCINOMA PREVIOUSLY TREATED BY CHEMOTHERAPY GOG 129-E - Endometrium - EVALUATION OF DACTINOMYCIN (COSMEGEN) IN THE TREATMENT OF RECURRENT OR PERSISTENT ENDOMETRIAL CARCINOMA. GOG 127-J - Cervix - EVALUATION OF 9-CIS RETINOIC ACID(9-CRA.NSC#659722) IN PERSISTENT OR RECURRENT SQUAMOUS CELL CARCINOMA OF THE CERVIX PREVIOUSLY TREATED BY CHEMOTHERAPY GOG 127-C - Cervix - EVALUATION OF CISPLATIN AND PENTOXIFYLLIN IN ADVANCED OR RECURRENT SQUAMOUS CELL CARCINOMA OF THE CERVIX GOG 126-M - Ovary - Phase II Evaluation of Epothilone-B (BMS 247550) (IND #59699 NSC #710428) in the Treatment of Recurrent or Persistant Platinum and Paclitaxel Refractory Ovarian or Primary Peritoneal Cancer. GOG 126-E - Ovary - EVALUATION OF PACLITAXEL & SDZ PSC IN RECURRENT PLATINUM RESISTANT AND REFRACTORY OVARIAN CANCER GOG 126-D - Ovary - EVALUATION OF PYRAZOLOACRIDINE (PZA) IN RECURRENT PLATINUM RESISTANT AND REFRACTORY OVARIAN CANCER GOG 125 (1992-3) - Cervix - Phase II para-aortic RT with chemo 9869224 (1998) GOG 123 (1992-97) - Cervix - A RANDOMIZED COMPARISON OF RT & ADJUVANT HYSTERECTOMY VS RT & WKLY CISPLATIN & ADJUVANT HYSTERECTOMY IN PATIENTS WITH BULKY STAGE IB CARCINOMA OF THE CERVIX 10202166, 1999 GOG 122 - Endometrium - Advanced Stage III-IV, randomized to whole abdominal XRT vs doxorubicin-cisplatin. ASCO Abstract 2003 - "Whole abdominal radiotherapy versus combination doxorubicin-cisplatin chemotherapy in advanced endometrial carcinoma: A randomized phase III trial of the Gynecologic Oncology Group" Randall ME et al. GOG 120 (1992-97) - Cervix - A RANDOMIZED COMPARISON OF HYDROXYUREA VERSUS HYDROXYUREA, 5-FU INFUSION AND BOLUS CISPLATIN VERSUS WEEKLY CISPLATIN AS ADJUNCT TO RADIATION THERAPY IN PATIENTS WITH STAGE IIB, III, IVA CARCINOMA OF THE CERVIX AND NEGATIVE PARA-AORTIC NODES 10202165 (1999, Full text) 19823064 (2009) - age 55+ GOG 117 - Uterus/Carcinosarcoma - Adjuvant Ifosfamide And Mesna With Cisplatin In Patient With Completely Resected Stage I Or II Mixed Mesodermal Tumors Of The Uterus (Phase I) GOG 115 - Ovary/Stroma - BLEOMYCIN (NSC#125066), ETOPOSIDE(NSC#141540) AND CISPLATIN(NSC#119875)(BEP)AS 1ST-LINE THERAPY OF MALIGNANT TUMORS OF THE OVARIAN STROMA (GRANULOSA CELL, SERTOLI-LEYDIG TUMOR, AND UNCLASSIFIED SEX CORD STROMAL TUMOR) GOG 110 - Cervix - A RANDOMIZED STUDY OF CISPLATIN VS CISPLATIN PLUS DIBROMODULCITOL VS CISPLATIN PLUS IFOSFAMIDE AND MESNA IN STAGE IVB, RECURRENT, PERSISTANT SQUAMOUS CELL CARCINOMA OF THE CERVIX GOG 109 / Intergroup 0107 / SWOG 8797 / RTOG 91-12 (1991-96) - Cervix - A RANDOMIZED COMPARISON OF 5FU INFUSION + BOLUS CISPLATIN AS AN ADJUNCT TO RADIATION THERAPY, VS RADIATION ALONE IN SELECTED PATIENTS WITH STAGE 1-A2,1B,IIA, CARCINOMA OF THE CERVIX FOLLOWING RADICAL HYSTERECTOMY AND NODE DISSECTION 10764420 (2000) GOG 108 - Uterus/Carcinosarcoma - A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus 11063636 (2000) GOG 101 - Vulva - Preoperative chemo/RT for unresectable T3 or with bulky nodes. 9747823 (1998, for T3/T4), 11072157 (2000, for bulky nodes) 51-100 GOG 95 - Ovary -A Randomized Clinical Trial For The Treatment Of Women With Selected Stage IC And II(A,B,C) And Selected Stage 1A And 1B Ovarian Cancer, Phase III. GOG 94 (1986-94) - Endometrium - Phase II. Whole abdominal radiotherapy in the adjuvant treatment of patients with stage III and IV endometrial cancer. Also included Stage I-II papillary serous or clear cell. 15913742 (2005), 16213007 (2005, papillary serous or clear cell) GOG 92 (1988-95) - Cervix - Post-op, randomized to +/- RT. Risk factors. Sedlis 10329031 (1999), 16427212 (2006) GOG 88 (1991-1991) - Vulva - RT vs bilateral groin dissection. 1526880 (1992) GOG 87-D - Uterus/Sarcoma - A PHASE II TRIAL OF VP-16 IN PATIENTS WITH ADVANCED UTERINE SARCOMA GOG 87-B - Uterus/Sarcoma - A PHASE II TRIAL OF IFOSFAMIDE (NSC109724) AND THE UROPROTECTOR MESNA (NSC113891) IN THE TREATMENT OF RECURRENT OR ADVANCED UTERINE SARCOMAS GOG 86-A - Endometrium - MASTER PROTOCOL FOR PHASE II DRUG STUDIES IN TREATMENT OF ADVANCED OR RECURRENT CARCINOMA OF THE ENDOMETRIUm GOG 85 / SWOG 8695 (1986-90) - Cervix - RT + hydroxurea vs RT + cisplatin/5-FU 10334517 (1999) GOG 81-A - Endometrium - MASTER PROTOCOL FOR HORMONAL TREATMENT OF ADVANCED OR RECURRENT CARCINOMA OF THE ENDOMETRIUM GOG 74 - Vulva - Early Stage I Carcinoma of the Vulva Treated with Ipsilateral Superficial Inguinal Lymphadenectomy and Modified Radical Hemivulvectomy 19193428 (2009), 8623839 (1996), 1553164 (1992) GOG 73 - Vulva Melanoma - Malignant melanoma of the vulva treated by radical hemivulvectomy 8174062 (1994) GOG 71 / RTOG 84-12 (1984-91) - Cervix - TREATMENT OF PATIENTS WITH SUB-OPTIMAL (BULKY) STAGE 1B CARCINOMA OF THE CERVIX. A RANDOMIZED OF RADIATION THERAPY VS RADIATION PLUS ADJUVANT EXTRAFACIAL HYSTRECTOMY 12798694, 2003 - Keys GOG 56 (1981-85) - Cervix - RT with Hydroxyurea vs misonidazole. 3293456 (preliminary report, 1988), 8336190 (1993) Effect of thrombocytosis: 10926792 (2000) 1-50 GOG 49 (1981-84) - Cervix - Surgical staging. 2599466 (1989), 2227547 (1990), 1551060 (1992), 1733218 (1992) - ovarian met GOG 37 (1977-84) - Vulva - Pts with positive nodes (from GOG 36) randomized to pelvic LN dissection vs RT. 3785783 (1986), 19701032 (2009) GOG 36 (1977-84) - Vulva - Surgery-pathologic study after lymph node dissection. 8314530 (1993), 2014852 (1991) - Staging, 3578430 (1987) GOG 34 - Endometrium - Surgery + RT +/- doxorubicin 2298404 (1990) GOG 26-A - Other - MASTER PROTOCOL FOR PHASE II DRUG STUDIES IN TREATMENT OF ADVANCED, RECURRENT PELVIC MALIGNANCIES GOG 20 (1973-1982) - Uterine sarcomas and carcinosarcoma - Adjuvant doxorubicin vs. no additional tx. Some patients got RT, and this decreased vaginal recurrence rate. But no effect on survival. 3897471 (1985) GOG 19 (1973-6) - Cervix - Surgical staging. 7353805 (1980) GOG 16 - Endometrium - Preop vs. Postop RT Closed due to poor accrual GOG 4 - Cervix - Hydroxyurea or Placebo Combined with Radiation to Treat Stage IIIB and IV Cervical Cancer Confined to the Pelvis. 1193437 (1975), 110744 (1979) GOG 3 - Ovary - Treatment for Women with Disseminated or Recurrent Advanced Ovarian Cancer with Melphalan Alone in Combination with 5-Fluorouracil and Dactinomycin 7378989 (1980), GOG 2 - Ovary - Radiotherapy (RT), Chemotherapy (CT), and Combined Therapy in Stage III Epithelial Ovarian Cancer GOG 1 - Ovary - The Role of Adjuvant Therapy in Stage I Ovarian Cancer 6252780 (1980), 7078855 (No abstract) (1982)