Radiation Oncology/Radiobiology/Proteins

Protein Overview Protein Activity Pathway PARP Single strand damage recognition BER AP endonuclease Sugar reside excision BER DNA glycosylase Base excision BER DNA ligase I DNA ligation BER Long Patch DNA ligase III DNA ligation BER Short Patch DNA polymerase β Nucleotide repair BER Short Patch DNA polymerase δ/ε Nucleotide repair BER Long Patch Flap endonuclease 1 (FEN1) Endonuclease BER Long Patch PCNA Adapter protein BER Long Patch XRCC1 Complex with DNA ligase III BER Short Patch XPA-XPG ssDNA repair NER ERCC6 (CSB) DNA binding NER ERCC8 (CSA) ERCC6 binding NER Mre11-Rad50-Nbs1 (MRN) DSB recognition Endo/exonuclease DSB recognition HR BRCA1 MRN regulation HR Replication protein A (RPA) scaffold HR RAD51 DNA homologue search HR BRCA2 RAD51 loading HR FANC-D BRCA2 loading S-phase checkpoint HR RAD52 facilitation HR RAD54 facilitation HR TopIIIA helicase HR BLM helicase HR Ligase I DNA ligation HR Ku70/Ku80 DNA dsb scaffold NHEJ DNA-PKcs DNA dsb bridge NHEJ Artemis DNA endonuclease NHEJ Ligase IV DNA ligation NHEJ XRCC4 DNA ligation NHEJ ATM dsb response DNA dsb damage response ATR ssb response DNA ssb damage response H2AX histone DNA scaffolding p53 transcription factor genome control p21 CDK2/CDK4/cyclin inhibition cell cycle control cyclinD/CDK4 G1 phase cell cycle control cyclinE/CDK2 S phase cell cycle control cylinA/CDK2 S/G2 phase cell cycle control cyclinB/CDK1 G2/M phase cell cycle control Rb holds E2F in check cell cycle control E2F G1 transcription factor cell cycle control Chk1 S & G2 checkpoint cell cycle control Chk2 S & G2 checkpoint cell cycle control CDC25A S & G2 control cell cycle control CDC25C S & G2 control cell cycle control Fas ligand ligand apoptosis FAS receptor receptor apoptosis FADD adapter apoptosis Bid extrinsic pro-apoptotic apoptosis caspase 8 extrinsic pathway initiator apoptosis Bax/Bak/Bim/Puma intrinsic pro-apoptotic apoptosis Bcl-2/Bcl-xL anti-apoptotic apoptosis Apaf-1 apoptosome apoptosis caspase 9 intrinsic pathway apoptosis caspase 3 apoptosis executor apoptosis DFF DNA cleavage apoptosis IAPs inhibitors of apoptosis apoptosis