Radiation Oncology/Breast/Male breast cancer

Breast Cancer in Men Background References: 18042939 Male breast cancer accounts for <1% of all breast cancer cases in the US. BRCA2: Overall, 14% risk of being BRCA2+ (unselected patients with male breast cancer) Risk of BRCA2+ in 77% in men with breast cancer in families with hereditary breast cancer Risk for development of breast cancer in BRCA2+ man: 6.3% by age 70 9245992 ; 2.8% by age 70 and 6.9% by 8011170890; relative risk of 10217148771 BRCA1: Association is less clear than with BRCA2 Epidemiology MSKCC, 1999 (1973-94) 10463981 -- "Localized male breast carcinoma and family history. An analysis of 142 patients." (Hill A, Cancer. 1999 Sep 1;86(5):821-5.) 142 pts treated at MSKCC or Ochsner Clinic. 5-year OS 86%, 10-yr 64%. 15% of pts had a 1st degree relative with breast cancer. Conclusion: Family history did not affect the age at diagnosis, duration of symptoms, the stage, or survival. BRCA mutations NCI, 2007 18042939 -- "Breast cancer risk among male BRCA1 and BRCA2 mutation carriers." (Tai YC, J Natl Cancer Inst. 2007 Dec 5;99(23):1811-4.) Retrospective. 97 men with breast cancer identified in multicenter database of families with BRCA1 or BRCA2 mutations. Male BRCA1 carriers: cumulative risk of breast cancer by age 70 of 1.2% BRCA2: cumulative risk by age 70 of 6.8% Retrospective series MSKCC,1999 - 10463981 see above under Epidemiology Princess Margaret, 1999 (1955-96) 10091736 -- "Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996." (Goss PE, Cancer. 1999 Feb 1;85(3):629-39.) Retrospective. 229 pts over a 42 yr period. 5-yr DFS 47%, OS 53%, LC 91% References