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Radiation Oncology/Toxicity/Fertility
Reference material by Wikibooks contributors. This retains its source identity and is not 411 news reporting.
Fertility
Also please see Toxicity/Ovary
Also please see Toxicity/Testis
Also please see Toxicity/Pituitary
Also please see Toxicity/Pelvis (general information)
Childhood Cancer Survivor Study (1970-1986)
2009 PMID 19364965 -- "Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study." (Green DM, J Clin Oncol. 2009 Jun 1;27(16):2677-85. Epub 2009 Apr 13.)
Retrospective. 5,149 femarle CCCS 5-year survivors not surgically sterile and cohort of 1,441 randomly selected female siblings
Outcome: RR for ever being pregnant 0.81 (SS)
Negative predictors: hypothalamic/pituitary RT dose >=30 Gy (RR 0.61), ovarian/uterine RT dose >5 Gy (RR 0.56) or RT dose >10 Gy (RR 0.18), treatment with lomustine or cyclophosphamide, or summed alkylating agent dose (AAD) 3-4
Conclusion: Fertility decreased among female pediatric cancer survivors