Radiation Oncology/Toxicity/Emami

This page is for dosimetric correlations of normal tissue tolerance. Emami estimates Normal whole organ tissue tolerances (cGy)(adapted from Emami 1991 PMID 2032882) Organ TD 5/5     TD 50/5      Whole 2/3 1/3 Whole 2/3 1/3 Bladder 6500 8000 N/A 8000 8500 N/A Brachial plexus 6000 6100 6200 7500 7600 7700 Brain 4500 5000 6000 6000 6500 7500 Brainstem 5000 5300 6000 6500 – – Cauda equina 6000 – – 7500 – – Colon(obstruction,perforation,ulceration) 4500 – 5500 5500 – 6500 Ear(acute serous otitis) 3000 3000 3000 4000 4000 4000 Ear(chronic serous otitis) 5500 5500 5500 6500 6500 6500 Esophagus(stricture,perforation) 5500 5800 6000 6800 7000 7200 Femoral head 5200 – – 6500 – – Heart(pericarditis) 4000 4500 6000 5000 5500 7000 Kidney 2300 3000 5000 2800 4000 – Larynx(necrosis) 7000 7000 7900 8000 8000 9000 Larynx(edema) 4500 4500 – 8000 – – Lens 1000 – – 1800 – – Liver 3000 3500 5000 4000 4500 5500 Lung 1750 3000 4500 2450 4000 6500 Optic chiasm 5000 – – 6500 – – Optic nerve 5000 – – 6500 – – Parotid gland 3200 3200 – 4600 4600   Rectum(severe proctitis,necrosis,fistula,stenosis) 6000 – – 8000 – – Retina 4500 – – 6500 – – Rib cage – – 5000 – – 6500 Skin (100 cm2)5500 (30 cm2)6000 (10 cm2)7000 (100 cm2)6500 – – Spinal cord (20 cm)4700 (10 cm)5000 (5 cm)5000 – (10 cm)7000 (5 cm)7000 Small intestine(obstruction,perforation) 4000 – 5000 5500 – 6000 Stomach(ulceration,perforation) 5000 5500 6000 6500 6700 7000 TMJ mandible 6000 6000 6500 7200 7200 7700 Thyroid 4500     8000     Partial volume estimates See also: Normal tissue complication probability Emami provides partial volume radiation tolerance estimates for only a few organ sites. Other researchers' data: Full text No PMID — "Use of normal tissue tolerance doses into linear quadratic equation to estimate normal tissue complicatio probability." T. S. Kehwar, Ph.D., D.Sc. and S. C. Sharma, M.D. Radiation Oncology Online Journal (www.rooj.com). Tables 3 and 4 are most helpful. Full text No PMID — "Analytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model." T. S. Kehwar, D.Sc., DABR. Journal of Cancer Research and Therapeutics. See especially Table 4