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Using GNOME/Differences KDE
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In terms of the basic desktop layout, KDE more-closely follows a Windows style with a taskbar, start menu, and various other things. On the other hand, GNOME takes the Mac OS X approach, placing the task bar on top of the screen and a separate bar for currently-open applications (the Task Bar).
GNOME and KDE each have their own set of usability and accessibility guidelines:
GNOME Human Interface Guidelines
KDE Human Interface Guidelines
GNOME is built with the GTK toolkit while KDE uses Qt.
GNOME is mainly written in C and KDE in C++.
While KDE's interface is built using Qt toolkit, GTK is a very popular toolkit for Linux and so most apps have better integration with GNOME.