411 REFERENCE · Wikibooks
Radiation Oncology/Radiobiology/Radiobiology and lung
Reference material by Wikibooks contributors. This retains its source identity and is not 411 news reporting.
RADIATION INJURY IN LUNG:
Pneumocytes type II —> main target of radiation
Earliest response to radiation
==> decrease in lamellar bodies
==> increase in alveolar surfactant
By 18–63 weeks
Degeneration & sloughing into alveolar spaces
Inflammatory cytokines
IL-1α/β
TGF-β
PDGF
Collagen and fibronectin genes