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Radiation Oncology/Cancer Syndromes/Ataxia-Telangiectasia-Like Disorder
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Ataxia-Telangiectasia-Like Disorder
Online Mendelian Inheritance in Man Entry (Johns Hopkins)
Mutation in MRE11 (part of MRN complex)
Critical in recognition and repair of DNA double strand breaks
Cells are radiosensitive
Similar clinical features as Ataxia-Telangiectasia
Birmingham, UK; 2004 15279810 -- "Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis."(Taylor AM, DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1219-25.)
Review