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Reaktor/Hosts/Tracktion
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Traction is an audio/MIDI sequencer that is working fine with R4.
it supports Reaktor as a VST & VSTI.
VST & MIDIin Tracktion.
Tracktion also supports Multi in/out via the racks.
Those racks are also useful if you want to use Reaktor as a send fx within traction or if you need to send MIDI to an fx like the R4 libary's Classic Vocoder(for example).
the multi in/out & send fx tutorials in in french
And the Best Part of it is that it's FREE