17β-Aminoestrogen

Class of chemical compounds thumb|right|275px|class=skin-invert-image|Prolame, a 17β-aminoestrogen. 17β-Aminoestrogens are a group of synthetic, steroidal estrogens derived from estradiol which have an amine substitution in place of the hydroxyl group at the C17β position. Lemini C, Rubio-Póo C, Silva G, García-Mondragón J, Zavala E, Mendoza-Patiño N, Castro D, Cruz-Almanza R, Mandoki JJ Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame [17 beta-(4-hydroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol] and pentolame [17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol] Steroids 58 10 457–61 1993 8256254 10.1016/0039-128x(93)90002-5 54381037 González G, Alvarado-Vasquez N, Fernández-G JM, Cruz-Robles D, Del Valle L, Pinzón E, Torres I, Rodriguez E, Zapata E, Gómez-Vidales V, Montaño LF, de la Peña A The antithrombotic effect of the aminoestrogen prolame (N-(3-hydroxy-1,3,5(10)-estratrien-17B-YL)-3-hydroxypropylamine) is linked to an increase in nitric oxide production by platelets and endothelial cells Atherosclerosis 208 1 62–8 2010 19615684 10.1016/j.atherosclerosis.2009.06.017 They are estrogenic similarly, but, unlike estradiol, show sustained anticoagulant activity that appears to be mediated by non-genomic mechanisms. As such, it is thought that they may have a reduced risk of venous thromboembolism. The 17β-aminoestrogens include the base or parent estrogen aminoestradiol (AE2) Lemini C, Rubio-Póo C, Franco Y, Jaimez R, Avila ME, Medina M, Lemus AE In vivo profile of the anticoagulant effect of 17ß-amino-1,3,5(10)estratrien-3-ol Eur. J. Pharmacol. 700 1–3 210–6 2013 23305838 10.1016/j.ejphar.2012.12.030 and the extended-chain derivatives butolame, hexolame, pentolame, prodiame, and prolame. They are a homologous series of steroids. Rubio-Póo C, Lemini C, Silva G, García-Mondragón J, Zavala E, Castro D, Mendoza-Patiño N, Mandoki JJ Comparison of the time course of anticoagulant and estrogenic effects of prolame, butolame, pentolame and hexolame, a homologous series of 17 beta-amino estrogens Proc. West. Pharmacol. Soc. 36 143–7 1993 8378368 References 30em Category:Secondary amines Category:Anticoagulants Category:Estranes Category:Synthetic estrogens