1854 Broad Street cholera outbreak

Severe outbreak of cholera that occurred in London in 1854 August 2017August 2022 1854 Broad Street cholera outbreak Pump Handle - John Snow .jpg An old-fashioned water pump, painted black, with its handle removed, standing on a stone pedestal two steps above the sidewalk A replica pump commemorating the outbreak and John Snow's investigation of it 1854 Soho, London, UK 51 30 48 N 00 08 12 W type:event_region:GB inline,title Vibrio cholerae present within the pumping water due to contamination by sewage 420 1846–1860 cholera pandemic A severe outbreak of cholera occurred in 1854 near Broad Street (now Broadwick Street) and Golden Square in Soho, London, England, during the worldwide 1846–1860 cholera pandemic. The outbreak (also known as Golden Square outbreakBrody Howard Rip Michael Russell Vinten-Johansen Peter Paneth Nigel Rachman Stephen Map-making and myth-making in Broad Street: the London cholera epidemic, 1854 The Lancet July 2000 356 9223 64–68 10.1016/S0140-6736(00)02442-9 10892779 23 June 2025 https://linkinghub.elsevier.com/retrieve/pii/S0140673600024429 subscription ), which killed 420 people, is best known for the physician John Snow's study of its causes and his hypothesis that germ-contaminated water was the cause, rather than something in the air called "miasma".Eyeler William July 2001 The changing assessments of John Snow's and William Farr's Cholera Studies Sozial- und Präventivmedizin 10.1007/BF01593177 11582849 46 4 225–32 9549345 free 10.1007/BF01593177 free This discovery influenced public health and the construction of improved sanitation facilities beginning in the mid-19th century. Later, the term "focus of infection" was used to describe sites, such as the Broad Street pump, where conditions are favourable for transmission of infection. Snow unknowingly took advantage of a natural experiment during his endeavours to identify the cause of cholera transmission. Background thumb|A Court for King Cholera. Illustration from Punch (1852). In the mid-19th century, Soho in London had a serious problem with filth due to a large influx of people and lack of proper sanitary services: the London sewer system had not reached Soho. Cowsheds, slaughterhouses and grease-boiling dens lined the streets and contributed animal droppings, rotting fluids and other contaminants to Soho's primitive sewer system.http://www.ph.ucla.edu/epi/snow/broadstreetpump.html Broad Street Pump Outbreak Frerichs Ralph R. www.ph.ucla.edu 2017-02-24 1 December 2016 https://web.archive.org/web/20161201162025/http://www.ph.ucla.edu/epi/snow/broadstreetpump.html live Many cellars had cesspools beneath their floorboards, which formed from the sewers and filth seeping in from outside. With the cesspools overrunning, London's government decided to dump the waste into the River Thames, contaminating the water supply.Paneth Nigel Vinten-Johansen Peter A Rivalry of Foulness: Official and Unofficial Investigations of the London Cholera Epidemic of 1854 American Journal of Public Health October 1998 88 10 1545–1553 10.2105/ajph.88.10.1545 9772861 1508470 London had already had a "series of debilitating cholera outbreaks".http://www.atlasobscura.com/places/broad-street-cholera-pump Broad Street Cholera Pump Atlas Obscura en 2017-02-24 24 February 2017 https://web.archive.org/web/20170224220033/http://www.atlasobscura.com/places/broad-street-cholera-pump live These included outbreaks in 1832 and 1849, which killed 14,137 people. Competing theories of cholera At the time of the Broad Street outbreak, physicians and scientists held two competing theories on the causes of cholera in the human body: miasma theory and germ theory.http://www.ph.ucla.edu/epi/snow/choleratheories.html Competing Theories of Cholera Frerichs Ralph R. www.ph.ucla.edu 2017-03-05 30 June 2017 https://web.archive.org/web/20170630175957/http://www.ph.ucla.edu/epi/snow/choleratheories.html live The London medical community debated the cause of the city's persistent cholera outbreaks. The cholera-causing bacterium Vibrio cholerae was isolated in 1854, but the finding became well known and accepted only decades later.Ralph Frerichs https://www.britannica.com/biography/John-Snow-British-physician John Snow British physician Encyclopedia Britannica 2017-07-28 12 June 2018 https://web.archive.org/web/20180612145037/https://www.britannica.com/biography/John-Snow-British-physician live Miasma theory Miasma theory Miasma theorists concluded that cholera was caused by particles in the air, or "miasmata", which arose from decomposing matter or other dirty organic sources. "Miasma" particles were thought to travel through the air and infect individuals, and thus cause cholera. Dr William Farr, the commissioner for the 1851 London census and a member of the General Register's Office, believed that miasma arose from the soil surrounding the River Thames. It contained decaying organic matter which contained miasmatic particles and was released into the London air. Miasma theorists believed in "cleansing and scouring, rather than through the purer scientific approach of microbiology". Farr later agreed with Snow's germ theory following Snow's publications. Germ theory Germ theory of disease In contrast, the germ theory held that the principal cause of cholera was a germ cell that had not yet been identified. Snow theorised that this unknown germ was transmitted from person to person by individuals ingesting water. John Simon, a pathologist and London's lead medical officer, called Snow's germ theory "peculiar". Excerpt from John Simon: This doctrine is, that cholera propagates itself by a 'morbid matter' which, passing from one patient in his evacuations, is accidentally swallowed by other persons as a pollution of food or water; that an increase of the swallowed germ of the disease takes place in the interior of the stomach and bowels, giving rise to the essential actions of cholera, as at first a local derangement; and that 'the morbid matter of cholera having the property of reproducing its own kind must necessarily have some sort of structure, most likely that of a cell. Even though Simon understood Snow's theory, he questioned its relation to the cause of cholera. Broad Street outbreak On 31 August 1854, after several other outbreaks elsewhere in the city, there was a major outbreak of cholera in Soho. Snow later called it "the most terrible outbreak of cholera which ever occurred in this kingdom."Epidemiology 101 Robert Friis Jones & Bartlett 13 Over the next three days, 127 people on or near Broad Street died. During the next week, three quarters of the residents had fled the area. By 10 September, more than 300 people had died and the mortality rate was 12.8 per thousand inhabitants in some parts of the city.https://books.google.com/books?id=7XsaAAAAMAAJ&pg=PA854 854 A History of Epidemics in Britain Charles Creighton Cambridge University Press 1894 21 January 2024 22 January 2024 https://web.archive.org/web/20240122062841/https://books.google.com/books?id=7XsaAAAAMAAJ&pg=PA854#v=onepage&q&f=false live By the end of the outbreak, 420 people had died.https://books.google.com/books?id=YSEEAAAAQAAJ&pg=PA579 579 The Irish Ecclesiastical Record V January 1884 Browne and Nolan Dublin 21 January 2024 22 January 2024 https://web.archive.org/web/20240122062846/https://books.google.com/books?id=YSEEAAAAQAAJ&pg=PA579#v=onepage&q&f=false live Many of the victims were taken to the Middlesex Hospital, where their treatment was superintended by Florence Nightingale, who briefly joined the hospital in early September in order to help with the outbreak. According to a letter by Elizabeth Gaskell, Nightingale "was up night and day from Friday afternoon (Sept. 1) to Sunday afternoon, receiving the poor creatures (chiefly fallen women of that neighbourhood - they had it the worst) who were being constantly brought in - - undressing them - putting on turpentine stupes, et cetera, doing it herself to as many as she could manage".O'Malley Ida Florence Nightingae, 1820-1856, A Study of Her Life Down to the End of the Crimean War 1931 Thornton Butterworth London 208 By talking to local residents (with the help of Reverend Henry Whitehead), Snow identified the outbreak's source as the public water pump on Broad Street (now Broadwick Street) at Cambridge Street. Although Snow's chemical and microscope examination of a sample of the water from this Broad Street pump water did not conclusively prove its danger, the patterns of illness and death among residents in Soho persuaded the St James parish authorities to disable the pump by removing its handle.Begum Fahema Mapping disease: John Snow and Cholera Royal College of Surgeons 2016-12-09 https://www.rcseng.ac.uk/library-and-publications/library/blog/mapping-disease-john-snow-and-cholera/ 2024-06-26 Although this action has been popularly reported as ending the outbreak, the epidemic may have already been in rapid decline, as explained by Snow: There is no doubt that the mortality was much diminished, as I said before, by the flight of the population, which commenced soon after the outbreak; but the attacks had so far diminished before the use of the water was stopped, that it is impossible to decide whether the well still contained the cholera poison in an active state, or whether, from some cause, the water had become free from it.Snow 1855 38 Snow later used a dot map to illustrate how cases of cholera occurred around this pump.Snow 1855 45 His efforts to connect the incidence of cholera with potential geographic sources was based on what is now known as a Voronoi diagram. He mapped the individual water pumps and generated cells representing all the points on his map that were closest to each pump. The section of Snow's map representing areas in the city where the closest available source of water was the Broad Street pump had the highest incidence of cholera. Snow also performed a statistical comparison between the Southwark and Vauxhall Waterworks Company and a waterworks at Seething Wells (owned by the Lambeth Waterworks Company) that was further upriver and hence had cleaner water; he showed that houses supplied by the former had a cholera mortality rate 14 times that of those supplied by the latter.Location of water companies https://www.ph.ucla.edu/epi/snow/watercompanies.html www.ph.ucla.edu 17 May 2020 15 February 2020 https://web.archive.org/web/20200215212047/http://www.ph.ucla.edu/epi/snow/watercompanies.html live Proof from Seething Wells http://seethingwellswater.org/Proof_from_Seething_Wells.html seethingwellswater.org 17 May 2020 6 June 2020 https://web.archive.org/web/20200606175614/http://seethingwellswater.org/Proof_from_Seething_Wells.html live Of the decline in cases related to the Broad Street pump, Snow said: It will be observed that the deaths either very much diminished, or ceased altogether, at every point where it becomes decidedly nearer to send to another pump than to the one in Broad street. It may also be noticed that the deaths are most numerous near to the pump where the water could be more readily obtained.Snow 1855 There was one significant anomaly: none of the workers in the nearby Broad Street brewery contracted cholera. As they were given a daily allowance of beer, they did not consume water from the nearby well.Snow 1855 42 During the brewing process, the wort (un-fermented beer) is boiled in part so that hops can be added. This step killed the cholera bacteria in the water they used to brew with, making it safe to drink. Snow showed that the Southwark and Vauxhall Waterworks Company was taking water from sewage-polluted sections of the Thames and delivering it to homes, resulting in an increased incidence of cholera among its customers. Snow's study is part of the history of public health and health geography. It is regarded as the founding event of epidemiology.Tulchinsky Theodore H. Case Studies in Public Health John Snow, Cholera, the Broad Street Pump; Waterborne Diseases Then and Now Elsevier 2018 978-0-12-804571-8 10.1016/b978-0-12-804571-8.00017-2 77–99 In Snow's own words: On proceeding to the spot, I found that nearly all the deaths had taken place within a short distance of the [Broad Street] pump. There were only ten deaths in houses situated decidedly nearer to another street-pump. In five of these cases the families of the deceased persons informed me that they always sent to the pump in Broad Street, as they preferred the water to that of the pumps which were nearer. In three other cases, the deceased were children who went to school near the pump in Broad Street ... With regard to the deaths occurring in the locality belonging to the pump, there were 61 instances in which I was informed that the deceased persons used to drink the pump-water from Broad Street, either constantly or occasionally ... The result of the inquiry then was, that there had been no particular outbreak or prevalence of cholera in this part of London except among the persons who were in the habit of drinking the water of the above-mentioned pump-well. I had an interview with the Board of Guardians of St. James's parish, on the evening of Thursday, the 7th September, and represented the above circumstances to them. In consequence of what I said, the handle of the pump was removed on the following day.Snow 1855 39-40 It was discovered later that this public well had been dug 3 ft 1 from an old cesspit that had begun to leak faecal bacteria. Waste water from washing nappies used by a baby who had contracted cholera from another source drained into this cesspit. Its opening was under a nearby house that had been rebuilt further away after a fire and a street widening. At the time there were cesspits under most homes. Most families tried to have their raw sewage collected and dumped in the Thames to prevent their cesspit from filling faster than the sewage could decompose into the soil.Klein G. Seeing what Others Don't: The Remarkable Ways We Gain Insights Nicholas Brealey Publishing 2014 978-1-85788-619-1 https://books.google.com/books?id=ececngEACAAJ 2024-06-26 74 At the same time, an investigation of cholera transmission was being conducted in Deptford. Around 90 people died within a few days in that town, where the water was known to be clean, and there had been no previous outbreaks of cholera. Snow was informed that the water had recently turned impure. Before using it, residents had to let it run until the sudsy, sewer-like water turned clear. Snow, finding that the water the residents were using was no different from the usual water from their pump, determined that the outbreak must be caused by a leak in the pipes that allowed surrounding sewage and its contaminants to seep in to the water supply. This was similar to the Broad Street outbreak. The incoming water was being contaminated by the increasing levels of sewage, coupled with lack of safe plumbing.Snow 1855 After the cholera epidemic subsided, government officials replaced the Broad Street pump handle. They had responded only to the urgent threat posed to the population, and afterwards they rejected Snow's theory. To accept his proposal would have meant indirectly accepting the oral-faecal method of transmission of disease, which was too unpleasant for most of the public to contemplate.Frank Chapelle, Wellsprings, New Brunswick, New Jersey: Rutgers University Press, 2005, p. 82 Investigation by John Snow thumb|upright=1.3|Original map by John Snow showing the clusters of cholera cases (indicated by stacked rectangles) in the London epidemic of 1854. The contaminated pump is located at the crossroads of Broad Street and Cambridge Street (now Lexington Street), running into Little Windmill Street. The Broad Street outbreak was an effect rather than a cause of the epidemic. Snow's conclusions were not predominantly based on the Broad Street outbreak, as he noted that he hesitated to come to a conclusion based on a population that had predominantly fled the neighbourhood and redistributed itself. He feared throwing off results of the study.Snow 1855 From a mathematical perspective, Snow's innovation was focusing on death rates in areas served by two water companies that drew water from the Thames, rather than basing it on data from victims of the Broad Street pump (which drew water from a well). Snow's work also led to a far greater health and safety impact than the removal of the Broad Street pump handle. Deactivating the pump "hardly made a dent in the citywide cholera epidemic, which went on to claim nearly 3,000 lives".The Book of Why Pearl Judea Basic Books 2018 New York 246 his most brilliant idea Snow was sceptical of the prevailing miasma theory, which held that diseases such as cholera or the Black Death were caused by pollution or a noxious form of "bad air". The germ theory was not yet established (Louis Pasteur proposed it in 1861). Snow did not understand the mechanism by which disease was transmitted, but the evidence led him to believe that it was not foul air. Based on the pattern of illness among residents, he hypothesized that cholera was spread by an agent in contaminated water. He first published his theory in 1849, in an essay titled "On the Mode of Communication of Cholera".Snow John John Snow 1849 On the Mode of Communication of Cholera London John Churchill https://collections.nlm.nih.gov/ext/cholera/PDF/0050707.pdf 20 May 2017 30 August 2019 https://web.archive.org/web/20190830175938/https://collections.nlm.nih.gov/ext/cholera/PDF/0050707.pdf live In 1855 he published a second edition, including a more elaborate investigation of the effect of the water supply in the 1854 Soho outbreak.Snow 1855 The cholera epidemic of 1849–1854 was also related to the water supplied by companies in London at the time. The main players were the Southwark and Vauxhall Waterworks Company and the Lambeth Waterworks Company. Both provided water to their customers drawn from the Thames, which was highly contaminated with visible and invisible products and bacteria. Dr Arthur Hill Hassall examined the filtered water and found it contained animal hair, among other foul substances. He remarked: It will be observed, that the water of the companies of the Surrey Side of London, viz., the Southwark, Vauxhall, and Lambeth, is by far the worst of all those who take their supply from the ThamesSnow 1855 Other companies, such as the New River Company and Chelsea Waterworks Company, were observed to have better filtered water; few deaths occurred in the neighbourhoods they supplied. They not only obtained their water from cleaner sources than the Thames, but filtered the water and treated it until there were no obvious contaminants.Snow 1855 As mentioned above, Snow is known for his influence on public health, which arose after his studies of the cholera epidemic. In attempting to figure out who was receiving impure water in each neighbourhood, what is now known as a double-blind experiment fell right into his lap. He describes the conditions of the situation in his essays: In many cases a single house has a supply different from that on either side. Each company supplies both rich and poor, both large houses and small; there is no difference in the condition or occupation of the persons receiving the water of the different companies...As there is no difference whatever either in the houses or the people receiving the supply of the two Water Companies, or in any of the physical conditions with which they are surrounded, it is obvious that no experiment could have been devised which would more thoroughly test the effect of water supply on the progress of Cholera than this, which circumstances placed ready made before the observer. The experiment too, was on the grandest scale. No fewer than three hundred thousand people of both sexes, of every age and occupation, and of every rank and station, from gentlefolks down to the very poor, were divided into two groups without their choice, and, in most cases, without their knowledge; one group being supplied water containing the sewage of London, and amongst it, whatever might have come from the cholera patients, the other group having water quite free from such impurity.Snow 1855 Snow went on to study the water contents from each home through a test performed on each sample. In this way, it could be deduced from which supplier the home received its water. He concluded that it was indeed impure water from the big companies that allowed cholera to spread rapidly. He proved this by observing London prisons, finding that cholera ceased there only a few days after switching to cleaner water sources.Snow 1855 Snow's post-outbreak evaluation Snow's analysis of cholera and cholera outbreaks extended past the closure of the Broad Street pump. He concluded that cholera was transmitted through and affected the alimentary canal within the human body. Cholera did not affect either the circulatory or the nervous system and there was no "poison in the blood...in the consecutive fever...the blood became poisoned from urea getting into the circulation". According to Snow, this "urea" entered the blood through kidney failure. (Acute kidney failure is a complication of cholera.)Knobel B. Rudman M. Smetana S. 1995-12-15 [Acute renal failure as a complication of cholera] Harefuah 129 12 552–555, 615 0017-7768 8682355 Therefore, the fever was caused by kidney failure, not by a poison already present in the subject's bloodstream. Popular medical practices, such as bloodletting, could not be effective in such a case. Snow also argued that cholera was not a product of Miasma. "There was nothing in the air to account for the spread of cholera". According to Snow, cholera was spread by persons ingesting a substance, not through atmospheric transmittal. Involvement of Henry Whitehead thumb|upright=0.8|Rev. Henry Whitehead The Reverend Henry Whitehead was an assistant curate at St. Luke's church in Soho during the 1854 cholera outbreak.Reverend Henry Whitehead https://www.ph.ucla.edu/epi/snow/whitehead.html 2024-06-25 Fielding School of Public Health 16 December 2007 https://web.archive.org/web/20071216094434/http://www.ph.ucla.edu/epi/snow/whitehead.html dead A former believer in the miasma theory of disease, Whitehead worked to disprove false theories. He was influenced by Snow's theory that cholera spreads by consumption of water contaminated by human waste. Snow's work, particularly his maps of the Soho area cholera victims, convinced Whitehead that the Broad Street pump was the source of the local infections. Whitehead joined Snow in tracking the contamination to a faulty cesspool and the outbreak's index case (the baby with cholera).Johnson Steven Steven Berlin Johnson The Ghost Map: The Story of London's Most Terrifying Epidemic – and How it Changed Science, Cities and the Modern World Riverhead Books 2006 206 978-1-59448-925-9 The Ghost Map Whitehead's work with Snow combined demographic study with scientific observation, setting an important precedent for epidemiology.Frerichs Ralph R Reverend Henry Whitehead 11 October 2006 http://www.ph.ucla.edu/epi/Snow/whitehead.html 2007-12-10 https://web.archive.org/web/20071216094434/http://www.ph.ucla.edu/epi/snow/whitehead.html 16 December 2007 live Board of Health The London Board of Health, which had recently been given new powers and was presided over by Sir Benjamin Hall, a Cabinet Minister, had several committees, of which the Committee for Scientific Inquiries was placed in charge of investigating the cholera outbreak. They were to study the atmospheric environment in London and to examine samples of water from several London water companies. The committee found that the most contaminated water supply came from the South London water companies, Southwark and Vauxhall.Paneth N Vinten-Johansen P Brody H Rip M 1998-10-01 A rivalry of foulness: official and unofficial investigations of the London cholera epidemic of 1854. American Journal of Public Health 88 10 1545–1553 0090-0036 1508470 9772861 10.2105/ajph.88.10.1545New Board of Health https://www.findmypast.co.uk/image-viewer?issue=BL%2F0000167%2F18540812&page=4&article=011&stringtohighlight=benjamin+hall+health Huddersfield Chronicle 12 August 1854 4 col4 As part of the Committee for Scientific Inquiries, Richard Dundas Thomson and Arthur Hill Hassall examined what Thomson called "vibriones". Thomson examined the occurrence of vibriones in air samples from various cholera wards and Hassall observed vibriones in water samples. Neither identified vibriones as the cause of cholera. As part of its investigation of the cholera epidemic, the Board of Health sent physicians to examine in detail the conditions of the Golden Square neighbourhood and its inhabitants. The Board of Health ultimately attributed the 1854 epidemic to miasma. Dr Edwin Lankester's evaluation Dr Edwin Lankester was a physician on the local research conglomerate that studied the 1854 Broad Street cholera epidemic. In 1866, Lankester wrote about Snow's conclusion that the pump caused the outbreak. He agreed with Snow at the time, but his opinion, like Snow's, was not publicly supported. Lankester subsequently closed the pump due to Snow's theory and data on the pattern of infection, and infection rates dropped significantly. He was eventually named the first medical officer of health for St James's parish in London, the area where the pump was.http://www.ph.ucla.edu/epi/snow/removal.html John Snow and the removal of the Broad Street pump handle Frerichs Ralph R. www.ph.ucla.edu 2017-03-05 Dr. Edwin Lankester wrote: 'The Board of Guardians met to consult as to what ought to be done. Of that meeting, the late Dr. Snow demanded an audience. He was admitted and gave it as his opinion that the pump in Broad Street, and that pump alone, was the cause of all the pestilence. He was not believed – not a member of his own profession, not an individual in the parish believed that Snow was right. But the pump was closed nevertheless and the plague was stayed.' 28 June 2018 https://web.archive.org/web/20180628172320/http://www.ph.ucla.edu/epi/snow/removal.html live Broadwick Street pump in the 21st century A replica pump was installed in 1992 at the site of the 1854 pump. Every year the John Snow Society holds "Pumphandle Lectures" on public health subjects. Until 2015, when the pump was removed due to redevelopment, it also held a ceremony there in which it removed and reattached the pump handle to commemorate Snow's discovery. The pump's original location is marked by a red granite paver, and plaques at the John Snow pub at the corner describe Snow's findings.http://www.atlasobscura.com/places/broad-street-cholera-pump Broad Street Cholera Pump Atlas Obscura en 2017-03-05 24 February 2017 https://web.archive.org/web/20170224220033/http://www.atlasobscura.com/places/broad-street-cholera-pump live Gallery See also London Medicine Epidemiology of tuberculosis Filippo Pacini Great Stink Joseph Bazalgette The Ghost Map William Budd Diseases and epidemics of the 19th century History of public health in the United Kingdom References 30em Sources Snow John John Snow 1855 On the Mode of Communication of Cholera 2nd London John Churchill https://archive.org/stream/b28985266#page/n3/mode/2up See also: Mode of Communication of Cholera(John Snow, 1855) Further reading Ball Laura 2009 Cholera and the Pump on Broad Street: The Life and Legacy of John Snow The History Teacher 43 1 105–119 40543358 Vinten-Johansen Peter https://books.google.com/books?id=_93j18W7cvwC&q=John++snow++St++Thomas%27s++hospital Cholera, Chloroform, and the Science of Medicine: A Life of John Snow Brody Howard Paneth Nigel Rachman Stephen Rip Michael 2003 Oxford University Press 9780199747887 Oxford External links Interactive version of John Snow's Map (Ghost Map) (archived 22 October 2009) Microorganisms in water from the Broad Street Pump https://www.youtube.com/watch?v=hkUCrTfgaw8 What Did John Snow Know About Cholera? – with James Grime 21 December 2020 Grime James video Royal Institution 21 December 2020 YouTube Category:1854 in London Category:1854 in science Category:1854 disasters Category:1854 in health Category:August 1854 Category:September 1854 Category:1850s epidemics Category:19th-century disease outbreaks Category:19th century in the City of Westminster 1854 Category:Health in London Category:Thames Water Category:Water supply and sanitation in London Category:Disease outbreaks in England Category:Soho, London Category:Health in the City of Westminster Category:Spatial epidemiology Category:History of medicine in the United Kingdom Category:1846–1860 cholera pandemic