2-deoxy-scyllo-inosose synthase

Enzyme Kanc the New Hampshire highway Kancamagus Highway 2-deoxy-scyllo-inosose synthase 4.2.3.124 2-deoxy-scyllo-Inosose synthase (EC 4.2.3.124, btrC (gene), neoC (gene), kanC (gene)) is an enzyme with systematic name D-glucose-6-phosphate phosphate-lyase (2-deoxy-scyllo-inosose-forming). Kudo F, Yamauchi N, Suzuki R, Kakinuma K Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose synthase derived from butirosin-producing Bacillus circulans The Journal of Antibiotics 50 5 424–8 May 1997 9207913 10.7164/antibiotics.50.424 free Kudo F, Hosomi Y, Tamegai H, Kakinuma K Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocyclization enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics The Journal of Antibiotics 52 2 81–8 February 1999 10344560 10.7164/antibiotics.52.81 free Kudo F, Tamegai H, Fujiwara T, Tagami U, Hirayama K, Kakinuma K Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase The Journal of Antibiotics 52 6 559–71 June 1999 10470681 10.7164/antibiotics.52.559 free Huang Z, Kakinuma K, Eguchi T Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics Bioorganic Chemistry 33 2 82–9 April 2005 15788164 10.1016/j.bioorg.2004.09.002 Thuy ML, Kharel MK, Lamichhane R, Lee HC, Suh JW, Liou K, Sohng JK Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans Biotechnology Letters 27 7 465–70 April 2005 15928851 10.1007/s10529-005-2222-y Tamegai H, Nango E, Koike-Takeshita A, Kudo F, Kakinuma K Significance of the 20-kDa subunit of heterodimeric 2-deoxy-scyllo-inosose synthase for the biosynthesis of butirosin antibiotics in Bacillus circulans Bioscience, Biotechnology, and Biochemistry 66 7 1538–45 July 2002 12224638 10.1271/bbb.66.1538 free Tamegai H, Sawada H, Nango E, Aoki R, Hirakawa H, Iino T, Eguchi T Roles of a 20 kDa protein associated with a carbocycle-forming enzyme involved in aminoglycoside biosynthesis in primary and secondary metabolism Bioscience, Biotechnology, and Biochemistry 74 6 1215–9 2010 20530911 10.1271/bbb.90961 free This enzyme catalyses the following chemical reaction D-glucose 6-phosphate 2-deoxy-L-scyllo-inosose + phosphate This enzyme requires Co2+. References External links 2-deoxy-scyllo-inosose+synthase Biology no Category:EC 4.2.3