17β-Hydroxysteroid dehydrogenase

Class of enzymes vanc July 2020 17β-Hydroxysteroid dehydrogenase 1.1.1.51 9015-81-0 0030283 17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (1.1.1.51), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.Dahm K, Breuer H 1964 Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte Precipitation of a 17-Beta-Hydroxysteroid:Nad(P) Oxidoreductase from the Rat Adrenal Gland Hoppe-Seyler's Zeitschrift für Physiologische Chemie German 336 63–8 10.1515/bchm2.1964.336.1.63 14214322Lynn WS, Brown RH June 1958 The conversion of progesterone to androgens by testes The Journal of Biological Chemistry 232 2 1015–30 10.1016/S0021-9258(19)77419-5 13549484 freeMarcus PI, Talalay P February 1956 Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases The Journal of Biological Chemistry 218 2 661–74 10.1016/S0021-9258(18)65833-8 13295221 freeSchultz RM, Groman EV, Engel LL June 1977 3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms The Journal of Biological Chemistry 252 11 3775–83 10.1016/S0021-9258(17)40319-X 193845 freeTalalay P, Dobson MM December 1953 Purification and properties of a beta-hydroxysteroid dehydrogenase The Journal of Biological Chemistry 205 2 823–37 10.1016/S0021-9258(18)49226-5 13129261 free This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol.Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Bélanger A January 1997 The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology Steroids 62 1 148–58 10.1016/S0039-128X(96)00174-2 9029730 54365519Brook Charles G. D. https://books.google.com/books?id=Y8nhO6D0k4cC&pg=PA288 Brook's Clinical Pediatric Endocrinology Truong Daniel Clayton Peter Carroll William Brown Rosalind John Wiley & Sons 2011 978-1-4443-1673-5 288 The major reactions catalyzed by 17β-HSD (such as the conversion of androstenedione to testosterone) are hydrogenation (reduction) reactions, rather than dehydrogenation (oxidation) reactions. Reactions thumb|450px|right|class=skin-invert-image|Steroidogenesis. 17β-HSD visible in bottom-left region. 17β-HSDs catalyze the following redox reactions of sex steroids:January 2026 20α-Hydroxyprogesterone ↔ Progesterone DHEA Dehydroepiandrosterone ↔ Androstenediol Androstenedione ↔ Testosterone Dihydrotestosterone ↔ 5α-Androstanedione / 3α-Androstanediol / 3β-Androstanediol Estrone ↔ Estradiol 16α-Hydroxyestrone ↔ Estriol Activity distribution thumb|left|350px|class=skin-invert-image|Distribution of 17β-HSD activities for formation of estradiol versus estrone in human tissues.Martel C, Rhéaume E, Takahashi M, Trudel C, Couët J, Luu-The V, Simard J, Labrie F March 1992 Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues J. Steroid Biochem. Mol. Biol. 41 3–8 597–603 10.1016/0960-0760(92)90390-5 1314080 54325300Michael Oettel https://books.google.com/books?id=0BfrCAAAQBAJ&pg=PA226 Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens Ekkehard Schillinger 6 December 2012 Springer Science & Business Media 978-3-642-58616-3 226 Genes Genes coding for 17β-HSD include: HSD17B1: Referred to as "estrogenic". Major subtype for activation of estrogens from weaker forms (estrone to estradiol and 16α-hydroxyestrone to estriol). Catalyzes the final step in the biosynthesis of estrogens. Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion of DHEA into androstenediol. Recently, has been found to inactivate DHT into 3α- and 3β-androstanediol.Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX April 2010 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production Molecular Endocrinology 24 4 832–45 10.1210/me.2009-0468 5417535 20172961 Expressed primarily in the ovaries and placenta but also at lower levels in the breast epithelium.Hilborn E, Stål O, Jansson A May 2017 Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer Oncotarget 8 18 30552–30562 10.18632/oncotarget.15547 5444764 28430630 Major isoform of 17β-HSD in the granulosa cells of the ovaries.Andersson S, Moghrabi N January 1997 Physiology and molecular genetics of 17 beta-hydroxysteroid dehydrogenases Steroids 62 1 143–7 10.1016/s0039-128x(96)00173-0 9029729 54341481 Mutations and associated deficiency have not been reported in humans.Jameson J. Larry https://books.google.com/books?id=UhjyBwAAQBAJ&pg=PA549 Principles of Molecular Medicine 13 July 1998 Springer Science & Business Media 978-1-59259-726-0 549 Knockout mice show altered ovarian sex steroid production, normal puberty, and severe subfertility due to defective luteinization and ovarian progesterone production.Hakkarainen J, Jokela H, Pakarinen P, Heikelä H, Kätkänaho L, Vandenput L, Ohlsson C, Zhang FP, Poutanen M September 2015 Hydroxysteroid (17β)-dehydrogenase 1-deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production FASEB Journal 29 9 3806–16 10.1096/fj.14-269035 26018678 free HSD17B2: Describable as "antiestrogenic" and "antiandrogenic".Wang CT, Li CF, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH, Liao KM 2016 High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract Journal of Cancer 7 15 2221–2230 10.7150/jca.16777 5166531 27994658 HSD17B2 has both anti-estrogenic and anti-androgenic functions. Major subtype for inactivation of estrogens and androgens into weaker forms (estradiol to estrone, testosterone to androstenedione, and androstenediol to DHEA). Also converts inactive 20α-hydroxyprogesterone into active progesterone. Preferential activity on androgens. Expressed widely in the body including in the liver, intestines, lungs, pancreas, kidneys, endometrium, prostate, breast epithelium, placenta, and bone.Melmed Shlomo https://books.google.com/books?id=YZ8_CwAAQBAJ&pg=PA904 Williams Textbook of Endocrinology Elsevier Health Sciences 2016 978-0-323-29738-7 904 16 July 2017 https://web.archive.org/web/20240504042311/https://books.google.com/books?id=YZ8_CwAAQBAJ&pg=PA904#v=onepage&q&f=false 4 May 2024 liveStrauss Jerome Frank https://books.google.com/books?id=KZ95AAAAQBAJ&pg=PA82 Yen and Jaffe's Reproductive Endocrinology Barbieri Robert L. 13 September 2013 Elsevier Health Sciences 978-1-4557-2758-2 82 16 July 2017 https://web.archive.org/web/20240504042340/https://books.google.com/books?id=KZ95AAAAQBAJ&pg=PA82#v=onepage&q&f=false 4 May 2024 live Said to be responsible for 17β-HSD activity in the endometrium and placenta.Jameson J. Larry https://books.google.com/books?id=xmLeBgAAQBAJ&pg=PA2078 Endocrinology: Adult and Pediatric E-Book De Groot Leslie J. 25 February 2015 Elsevier Health Sciences 978-0-323-32195-2 2078 17 July 2017 https://web.archive.org/web/20240504042321/https://books.google.com/books?id=xmLeBgAAQBAJ&pg=PA2078#v=onepage&q&f=false 4 May 2024 live Mutations and associated congenital deficiency have not been reported in humans. However, local deficiency in expression of HSD17B2 has been associated with endometriosis.Bulun SE, Cheng YH, Pavone ME, Yin P, Imir G, Utsunomiya H, Thung S, Xue Q, Marsh EE, Tokunaga H, Ishikawa H, Kurita T, Su EJ January 2010 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis Seminars in Reproductive Medicine 28 1 44–50 10.1055/s-0029-1242992 4511594 20108182 HSD17B3: Referred to as "androgenic". Major subtype in males for activation of androgens from weaker forms (androstenedione to testosterone and DHEA to androstenediol). Also activates estrogens from weaker forms to a lesser extent (estrone to estradiol). This is essential for testicular but not ovarian production of testosterone. Not expressed in the ovaries, where another 17β-HSD subtype, likely HSD17B5, is expressed instead. Mutations are associated with 17β-HSD 17β-Hydroxysteroid dehydrogenase type III deficiency. Males with this condition have pseudohermaphroditism, while females are normal with normal androgen and estrogen levels. HSD17B4: Also known as D-bifunctional protein (DBP). Involved in fatty acid β-oxidation and steroid metabolism (specifically estrone to estradiol, for instance in the uterus).Pierce SB, Walsh T, Chisholm KM, Lee MK, Thornton AM, Fiumara A, Opitz JM, Levy-Lahad E, Klevit RE, King MC August 2010 Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome American Journal of Human Genetics 87 2 282–8 10.1016/j.ajhg.2010.07.007 2917704 20673864 Mutations are associated with DBP deficiency and Perrault syndrome (ovarian dysgenesis and deafness). HSD17B5: Also known as aldo-keto reductase 1C3 (AKR1C3), encoded by the AKR1C3 gene in humans. Has 3α-HSD 3α-hydroxysteroid dehydrogenase and 20α-HSD 20α-hydroxysteroid dehydrogenase activity in addition to 17β-HSD activity. Expressed in the adrenal cortex and may act as the "androgenic" 17β-HSD in ovarian thecal cells. Also expressed in the prostate gland, mammary gland, and Leydig cells. HSD17B6: Has 3α-HSD 3α-hydroxysteroid dehydrogenase activity and catalyzes conversion of the weak androgen androstanediol into the powerful androgen dihydrotestosterone in the prostate gland. Also involved into a backdoor pathway from 17α-hydroxyprogesterone to dihydrotestosterone by 3α-reduction of a metabolic intermediary, 17α-hydroxydihydroprogesterone, into another intermediary, 17α-hydroxyallopregnanolone.Masiutin Maxim Yadav Maneesh 2023 Alternative androgen pathways WikiJournal of Medicine 10 X 10.15347/WJM/2023.003 257943362 free May be involved in the pathophysiology of PCOS polycystic ovary syndrome. HSD17B7: Is involved in cholesterol metabolism but is also thought to activate estrogens (estrone to estradiol) and inactivate androgens (dihydrotestosterone to androstanediol). Expressed in the ovaries, breasts, placenta, testes, prostate gland, and liver. HSD17B8: Inactivates estradiol, testosterone, and dihydrotestosterone, though can also convert estrone into estradiol. Expressed in the ovaries, testes, liver, pancreas, kidneys, and other tissues.Fomitcheva J, Baker ME, Anderson E, Lee GY, Aziz N August 1998 Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues The Journal of Biological Chemistry 273 35 22664–71 10.1074/jbc.273.35.22664 9712896 freeKikuti YY, Tamiya G, Ando A, Chen L, Kimura M, Ferreira E, Tsuji K, Trowsdale J, Inoko H June 1997 Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes Genomics 42 3 422–35 10.1006/geno.1997.4745 9205114 HSD17B9: Also known as retinol dehydrogenase 5 (RDH5). Involved in retinoid metabolism.Lidén M, Tryggvason K, Eriksson U December 2003 Structure and function of retinol dehydrogenases of the short chain dehydrogenase/reductase family Molecular Aspects of Medicine 24 6 403–9 10.1016/s0098-2997(03)00036-0 14585311 Mutations are associated with fundus albipunctatus.Skorczyk-Werner A, Pawłowski P, Michalczuk M, Warowicka A, Wawrocka A, Wicher K, Bakunowicz-Łazarczyk A, Krawczyński MR August 2015 Fundus albipunctatus: review of the literature and report of a novel RDH5 gene mutation affecting the invariant tyrosine (p.Tyr175Phe) Journal of Applied Genetics 56 3 317–27 10.1007/s13353-015-0281-x 4543405 25820994 HSD17B10: Also known as 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD). Substrates include steroids, neurosteroids, fatty acids, bile acids, isoleucine, and xenobiotics.Yang SY, He XY, Miller D 2011 Hydroxysteroid (17β) dehydrogenase X in human health and disease Mol. Cell. Endocrinol. 343 1–2 1–6 10.1016/j.mce.2011.06.011 21708223 8608312Yang SY, He XY, Isaacs C, Dobkin C, Miller D, Philipp M 2014 Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders J. Steroid Biochem. Mol. Biol. 143 460–72 10.1016/j.jsbmb.2014.07.001 25007702 free Mutations are associated with 17β-HSD 17β-Hydroxysteroid dehydrogenase type X deficiency (also known as HSD10 disease or MHBD deficiency) and mental retardation, X-linked, syndromic 10 (MRXS10), which are characterized by neurodegeneration and mental retardation, respectively. HSD17B11: very little is known on the role/function of this iszyme.Su W, Mao Z, Liu Y, Zhang X, Zhang W, Gustafsson J, Guan Y 2019 Role of HSD17B13 in the liver physiology and pathophysiology Molecular and Cellular Endocrinology 489 119–125 10.1016/j.mce.2018.10.014 30365983Bai R, Rebelo A, Kleeff J, Sunami Y 2021 Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis Lipids in Health and Disease 20 1 10.1186/s12944-021-01476-y 8171034 34078402 free 58 HSD17B12 HSD17B13 HSD17B14 At least 7 of the 14 isoforms of 17β-HSD are involved in interconversion of 17-ketosteroids and 17β-hydroxysteroids. Overview + Comparison and characteristics of human 17β-HSD isoenzymesZhu Yuan-Shan Hormones, Brain and Behavior Imperato-McGinley Julianne L. 9 November 2016 Elsevier Science 978-0-12-803608-2 Lightman Stafford 4: Clinical Important Effects of Hormones on Brain and Behavior 69 4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition https://books.google.com/books?id=NT8oCwAAQBAJ&pg=RA3-PA69Moeller G, Adamski J 2009 Integrated view on 17beta-hydroxysteroid dehydrogenases Mol. Cell. Endocrinol. 301 1–2 7–19 10.1016/j.mce.2008.10.040 19027824 30321495Mindnich R, Möller G, Adamski J 2004 The role of 17 beta-hydroxysteroid dehydrogenases Mol. Cell. Endocrinol. 218 1–2 7–20 10.1016/j.mce.2003.12.006 15130507 26877571Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J 2011 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development J. Steroid Biochem. Mol. Biol. 125 1–2 66–82 10.1016/j.jsbmb.2010.12.013 21193039 23767100 # Gene name Synonyms Family Size (AA Amino acids) Gene location Cellular location Substrate specificities Preferred cofactor Catalytic preference Tissue distribution Expression profile Pathology 1 HSD17B1 SDR Short-chain dehydrogenase 328 17q21.2 Cytosol Estrogens NADH, NADPH Reduction Ovary, endometrium, breast, brain, prostate, placenta Strongly restricted Breast cancer, prostate cancer, endometriosis 2 HSD17B2 SDR Short-chain dehydrogenase 387 16q23.3 ER Endoplasmic reticulum Estrogens, androgens, progestogens NAD+ Oxidation Liver, intestine, endometrium, placenta, pancreas, prostate, colon, bone Selectively distributed Breast cancer, prostate cancer, endometriosis, osteoporosisSoubhye J, Alard IC, van Antwerpen P, Dufrasne F 2015 Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis Future Med Chem 7 11 1431–56 10.4155/fmc.15.74 26230882 3 HSD17B3 SDR Short-chain dehydrogenase 310 9q22.32 ER Endoplasmic reticulum Androgens NADPH Reduction Testis, ovary, blood, saliva, skin, adipose tissue, brain, bone Strongly restricted 17β-HSD3 17β-Hydroxysteroid dehydrogenase 3 deficiency, prostate cancerNing X, Yang Y, Deng H, Zhang Q, Huang Y, Su Z, Fu Y, Xiang Q, Zhang S 2017 Development of 17β-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy Steroids 121 10–16 10.1016/j.steroids.2017.02.003 28267564 32062736 4 HSD17B4 DBP D-bifunctional protein, MFP2 Multifunctional protein 2 SDR Short-chain dehydrogenase 736 5q23.1 PXS Peroxisomes Fatty acids, bile acids, estrogens, androgens NAD+ Oxidation Liver, heart, prostate, testis, lung, skeletal muscle, kidney, pancreas, thymus, ovary, intestine, placenta, brain, spleen, colon, lymphocytes Ubiquitous DBP D-bifunctional protein deficiency, Perrault syndrome, prostate cancer 5 AKR1C3 Aldo-keto reductase family 1 member C3 HSD17B5, 3α-HSD2 3α-hydroxysteroid dehydrogenase type 2, PGFS Prostaglandin F synthase AKR Aldo-keto reductase 323 10p15.1 Nucleus, cytosol Androgens, progestogens, estrogens, prostaglandins NADPH Reduction Prostate, mammary gland, liver, kidney, lung, heart, small intestine, colon, uterus, testis, brain, skeletal muscle, adipose tissue Nearly ubiquitous Breast cancer, prostate cancer 6 HSD17B6 SDR Short-chain dehydrogenase 317 12q13.3 Endosomes Retinoids, androgens, estrogens NAD+ Oxidation Liver, testis, lung, spleen, brain, ovary, kidney, adrenal, prostate Selectively distributed ? 7 HSD17B7 SDR Short-chain dehydrogenase 341 1q23.3 PM Plasma membrane, ER Endoplasmic reticulum Cholesterol, estrogens, androgens, progestogens NADPH Reduction Ovary, corpus luteum, uterus, placenta, liver, breast, testis, brain, adrenal gland, small intestine, lung, thymus, prostate, adipose tissue, others Widely distributed Breast cancer 8 HSD17B8 SDR Short-chain dehydrogenase 261 6p21.32 MC Mitochondria Fatty acids, estrogens, androgens NAD+ Oxidation Prostate, placenta, kidney, brain, cerebellum, heart, lung, small intestine, ovary, testis, adrenal, stomach Widely distributed Polycystic kidney disease 9 RDH5 Retinol dehydrogenase 5 HSD17B9 318 12q13.2 ER Endoplasmic reticulum Retinoids NADH/NAD+ Reduction / oxidation Retina, liver, adipose tissue, blood, others ? Fundus albipunctatus 10 HSD17B10 MHBD 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase SDR Short-chain dehydrogenase 261 Xp11.2 MC Mitochondria Fatty acids, bile acids, estrogens, androgens, progestogens, corticosteroids NAD+ Oxidation Liver, small intestine, colon, kidney, heart, brain, placenta, lung, ovary, testis, spleen, thymus, prostate, peripheral blood leukocytes Nearly ubiquitous 17β-HSD10 17β-Hydroxysteroid dehydrogenase 10 deficiency, MRXS10 Mental retardation, X-linked, syndromic 10, Alzheimer's disease 11 HSD17B11 SDR Short-chain dehydrogenase 300 4q22.1 ER Endoplasmic reticulum, EP Extracellular space Estrogens, androgens NAD+ Oxidation Liver, pancreas, intestine, kidney, adrenal gland, heart, lung, testis, ovary, placenta, sebaceous gland Nearly ubiquitous ? 12 HSD17B12 SDR Short-chain dehydrogenase 312 11p11.2 ER Endoplasmic reticulum Fatty acids, estrogens, androgens NADPH Reduction Heart, skeletal muscle, liver, kidney, adrenal gland, testis, placenta, cerebellum, pancreas, stomach, small intestine, large intestine, trachea, lung, thyroid, esophagus, prostate, aorta, urinary bladder, spleen, skin, brain, ovary, breast, uterus, vagina Ubiquitous ? 13 HSD17B13 SDR Short-chain dehydrogenase 300 4q22.1 ER Endoplasmic reticulum, EP Extracellular space ? NAD+? Oxidation? Liver, bone marrow, lung, ovary, testis, kidney, skeletal muscle, brain, bladder, nasal epithelia Strongly restricted ? 14 HSD17B14 SDR Short-chain dehydrogenase 270 19q13.33 Cytosol Estrogens, androgens, fatty acids NAD+ Oxidation Liver, kidney, brain, gallbladder, breast, adrenal, placenta Widely distributed Breast cancer (prognostic) 15 RDH11 Retinol dehydrogenase 11Samson M, Labrie F, and Luu-The V 23 June 2012 Characterization of Type 15 17β-Hydroxysteroid Dehydrogenase Steroid Hormone Biosynthesis & Metabolism (Translational)Lin B, White JT, Ferguson C, Wang S, Vessella R, Bumgarner R, True LD, Hood L, Nelson PS 2001 Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium Cancer Res. 61 4 1611–8 11245473Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS 2002 Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1) J. Biol. Chem. 277 32 28909–15 10.1074/jbc.M202588200 12036956 free PSDR1 Prostate short-chain dehydrogenase/reductase 1, HSD17B15 SDR Short-chain dehydrogenase 318 14q23-24.3 ER Endoplasmic reticulum Retinoids, androgens NADPH Reduction Retina, prostate, brain, testis ? Retinitis pigmentosaXie YA, Lee W, Cai C, Gambin T, Nõupuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R 2014 New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11 Hum. Mol. Genet. 23 21 5774–80 10.1093/hmg/ddu291 4189905 24916380 Clinical significance Mutations in HSD17B3 are responsible for 17β-HSD 17β-hydroxysteroid dehydrogenase type III deficiency. Inhibitors of 17β-HSD type II are of interest for the potential treatment of osteoporosis.Perspicace E, Cozzoli L, Gargano EM, Hanke N, Carotti A, Hartmann RW, Marchais-Oberwinkler S August 2014 Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities European Journal of Medicinal Chemistry 83 317–37 10.1016/j.ejmech.2014.06.036 24974351 Some inhibitors of 17β-HSD type I have been identified, for example esters of cinnamic acid and various flavones (e.g. fisetin).Brozic P, Kocbek P, Sova M, Kristl J, Martens S, Adamski J, Gobec S, Lanisnik Rizner T March 2009 Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 https://hal.archives-ouvertes.fr/hal-00532074/document live Molecular and Cellular Endocrinology 301 1–2 229–34 10.1016/j.mce.2008.09.004 18835421 26950431 https://web.archive.org/web/20220304221754/https://hal.archives-ouvertes.fr/hal-00532074/document 4 March 2022 4 March 2022 See also Steroidogenic enzyme 3α-Hydroxysteroid dehydrogenase References 33em External links 3(or+17)beta-hydroxysteroid+dehydrogenase Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Enzymes of known structure Category:Steroid hormone biosynthesis