1-(2-Diphenyl)piperazine

Chemical compound 456495470 1-(2-diphenyl)piperazine 1-(2-diphenyl)piperazine.svg skin-invert-image 220 correct chemspider 2019031 correct chemspider 1S/C16H18N2/c1-2-6-14(7-3-1)15-8-4-5-9-16(15)18-12-10-17-11-13-18/h1-9,17H,10-13H2 correct chemspider RKRVRTJVCWZOQS-UHFFFAOYSA-N correct CAS 180698-18-4 correct FDA T5S5265H6V correct EBI 494675 2737389 16 18 2 C3CNCCN3c1ccccc1-c2ccccc2 1-(2-Diphenyl)piperazine, also known as RA-7, is a drug that acts as a potent and selective antagonist at the 5HT7 serotonin receptor. It was discovered as an active metabolite of the synthetic 5-HT7 agonists LP-12 and LP-211 and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules, despite its much simpler structure.Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor Neuroscience Letters 481 1 12–6 20600619 2910240 10.1016/j.neulet.2010.06.036 August 2010 See also Benzylpiperazine Naphthylpiperazine Phenylpiperazine References Category:Serotonin receptor agonists Category:Phenylpiperazines Category:1-Piperazinyl compounds