17β-Dihydroequilenin

Chemical compound vanc 17α-Dihydroequilin 17β-Dihydroequilin 17α-Dihydroequilenin (13S,14S,17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol 17β-Dihydroequilenin.svg skin-invert-image 225px By mouth Estrogen correct CAS 1423-97-8 correct FDA ET2MK3VGB4 3032407 2297390 123405 β-Dihydroequilenin; Δ6,8-17β-Estradiol; 6,8-Didehydro-17β-estradiol; Estra-1,3,5(10),6,8-pentaen-3,17β-diol 18 20 2 C[C@]12CCC3=C([C@@H]1CC[C@@H]2O)C=CC4=C3C=CC(=C4)O 1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2-5,10,16-17,19-20H,6-9H2,1H3/t16-,17-,18-/m0/s1 RYWZPRVUQHMJFF-BZSNNMDCSA-N 17β-Dihydroequilenin, or β-dihydroequilenin, also known as δ6,8-17β-estradiol or 6,8-didehydro-17β-estradiol, as well as estra-1,3,5(10),6,8-pentaen-3,17β-diol, is a naturally occurring steroidal estrogen found in horses which is closely related to equilin, equilenin, and estradiol, and, as the 3-sulfate ester sodium salt, is a minor constituent (0.5%) of conjugated estrogens (Premarin). Fritz MA, Speroff L Postmenopausal Hormone Therapy Clinical Gynecologic Endocrinology and Infertility https://books.google.com/books?id=KZLubBxJEwEC&pg=PA751 28 March 2012 Lippincott Williams & Wilkins 978-1-4511-4847-3 751– 17β-Dihydroequilenin has unexpectedly shown a selective estrogen receptor modulator (SERM)-like profile of estrogenic activity in studies with monkeys, in which beneficial effects on bone and the cardiovascular system were noted but proliferative responses in breast and endometrium were not observed. Cline JM Assessing the mammary gland of nonhuman primates: effects of endogenous hormones and exogenous hormonal agents and growth factors Birth Defects Research. Part B, Developmental and Reproductive Toxicology 80 2 126–146 April 2007 17443713 10.1002/bdrb.20112 See also List of estrogens Equine estrogens References Category:Secondary alcohols Category:Estranes Category:Estrogens