(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase

Class of enzymes (KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase 2.4.99.14 (KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase (2.4.99.14, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->8) glycosidic bond-forming). Löbau S, Mamat U, Brabetz W, Brade H Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183 Molecular Microbiology 18 3 391–9 November 1995 8748024 10.1111/j.1365-2958.1995.mmi_18030391.x Mamat U, Baumann M, Schmidt G, Brade H The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology Molecular Microbiology 10 5 935–41 December 1993 7523826 10.1111/j.1365-2958.1993.tb00965.x Belunis CJ, Mdluli KE, Raetz CR, Nano FE A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope The Journal of Biological Chemistry 267 26 18702–7 September 1992 10.1016/S0021-9258(19)37018-8 free 1382060 This enzyme catalyses the following chemical reaction alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes. References External links (KDO)2-lipid+IVA+(2-8)+3-deoxy-D-manno-octulosonic+acid+transferase Biology no Category:EC 2.4.99