(S)-norcoclaurine synthase

Class of enzymes vanc 6 (S)-norcoclaurine synthase 3.5.99.14 79122-01-3 0050474 The enzyme (S)-norcoclaurine synthase (3.5.99.14) catalyzes the chemical reaction: Stadler R, Kutchan TM, Zenk MH (S)-norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis Phytochemistry 28 4 1083–1086 1989 10.1016/0031-9422(89)80187-6 Samanani N, Facchini PJ Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants The Journal of Biological Chemistry 277 37 33878–33883 September 2002 12107162 10.1074/jbc.M203051200 free 4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (Dopamine) (S)-norcoclaurine + H2O thumb|center|upright=2.5|Biosynthesis of (S)-norcoclaurine from dopamine and 4-hydroxyphenylacetaldehyde This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in isoquinoline alkaloid biosynthesis. Tian Y, Kong L, Li Q, Wang Y, Wang Y, An Z, Ma Y, Tian L, Duan B, Sun W, Gao R, Chen S, Xu Z Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids Natural Product Reports 41 11 1787–1810 November 2024 39360417 10.1039/d4np00029c References Biology no Category:Enzymes of unknown structure Category:EC 3.5