2-deoxy-D-gluconate 3-dehydrogenase

Class of enzymes 2-deoxy-D-gluconate 3-dehydrogenase 1.1.1.125 37250-54-7 0008678 2-deoxy-D-gluconate 3-dehydrogenase (1.1.1.125) is an enzyme that catalyzes the chemical reaction 50% Q27098396 2-deoxy-D-gluconic acid + NAD+ reversible H+ H+ Q27102004 3-dehydro-2-deoxy-D-gluconic acid + NADH The two substrates of this enzyme are 2-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 3-dehydro-2-deoxy-D-gluconic acid, reduced NADH, and a proton.1.1.1.125 Eichhorn MM, Cynkin MA Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase Biochemistry 4 159–65 January 1965 14285233 10.1021/bi00877a024 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase. This enzyme is also called 2-deoxygluconate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions. Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1X1E. References Biology no Category:EC 1.1.1 Category:NADH-dependent enzymes Category:Enzymes of known structure