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1D-LSD
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October 2024
1D-LSD.svg skin-invert-image 200px 1D-LSD 3D.png bg-transparent 250px Oral1D-LSD АИПСИН https://aipsin.com/newsubstance/951/ ru 1 January 2026 Serotonergic psychedelic; Hallucinogen None 6–8 hours 3028950-67-3 170703347 1-(1,2-Dimethylcyclobutane-1-carbonyl)-LSD; 1-(1,2-Dimethylcyclobutane-1-carbonyl)-N,N-diethyllysergamide; SYN-L-229 (8β)-1-(1,2-Dimethylcyclobutane-1-carbonyl)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide 27 35 3 2 [H][C@@]12CC3=CN(C(=O)C4(C)CCC4C)C4=C3C(=CC=C4)C1=C[C@H](CN2C)C(=O)N(CC)CC 1S/C27H35N3O2/c1-6-29(7-2)25(31)19-13-21-20-9-8-10-22-24(20)18(14-23(21)28(5)15-19)16-30(22)26(32)27(4)12-11-17(27)3/h8-10,13,16-17,19,23H,6-7,11-12,14-15H2,1-5H3/t17?,19-,23-,27?/m1/s1 RNVFVHAKGPSAIU-ZRCBXKLVSA-N
1D-LSD, also known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-LSD or as SYN-L-229, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is believed to be a prodrug of LSD and replaced 1V-LSD in Germany after 1V-LSD became covered by the German NpSG law in 2022.Video Sky News 13 June 2024 Germany Stuttgart: LSD variant being sold in German vending machine due to legal loophole https://news.sky.com/video/stuttgart-lsd-variant-being-sold-in-german-vending-machine-due-to-legal-loophole-13152534
Use and effects
LSD#Uses LSD#Effects
1D-LSD has a dose of 10 to 350μg depending on the intended use, with blotter tabs typically containing 150μg. It is said to be roughly comparable in potency to 1V-LSD. 1D-LSD is said to have a much faster onset than 1V-LSD or LSD but to also have a shorter duration in comparison (6–8hours and 10–12hours, respectively).
Interactions
Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes
Chemistry
Analogues
Analogues of 1D-LSD include ALD-52 (1A-LSD), 1P-LSD, 1S-LSD, 1DD-LSD, 1V-LSD, 1cP-LSD, and 1T-LSD, among others.
History
1D-LSD was encountered online as a novel designer drug in October 2022 after 1V-LSD was prohibited in Germany in September 2022.
Society and culture
Legal status
Austria
According to the current legal situation, 1D-LSD is neither explicitly mentioned in the Narcotic Drugs Ordinance nor in the Psychotropic Substances Ordinance (SV/PV), thus it is neither to be classified as a narcotic drug in the sense of the SV nor as a psychotropic substance in the sense of the PV.
Canada
1D-LSD is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026
Germany
Since the 14 June 2024 1D-LSD (and 1T-LSD) are covered by the German NpSG law.
United States
1D-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
Substituted lysergamide
Lizard Labs
References
External links
1D-LSD - Isomer Design
1D-LSD - Bluelight
From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides - Sociedelic
Category:5-HT2A agonists
Category:Cyclobutanes
Category:Designer prodrugs
Category:Diethylamides
Category:Lizard Labs
Category:Methyl compounds
Category:Psychedelic lysergamides