1,8-cineole synthase

Class of enzymes 1,8-cineole synthase 4.2.3.108 110637-19-9 1,8-Cineole synthase (EC 4.2.3.108, 1,8-cineole cyclase, geranyl pyrophoshate:1,8-cineole cyclase, 1,8-cineole synthetase) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, 1,8-cineole-forming). Croteau R, Alonso WR, Koepp AE, Johnson MA Biosynthesis of monoterpenes: partial purification, characterization, and mechanism of action of 1,8-cineole synthase Archives of Biochemistry and Biophysics 309 1 184–192 February 1994 8117108 10.1006/abbi.1994.1101 Wise ML, Savage TJ, Katahira E, Croteau R Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase The Journal of Biological Chemistry 273 24 14891–14899 June 1998 9614092 10.1074/jbc.273.24.14891 free Peters RJ, Croteau RB Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases Archives of Biochemistry and Biophysics 417 2 203–211 September 2003 12941302 10.1016/s0003-9861(03)00347-3 Chen F, Ro DK, Petri J, Gershenzon J, Bohlmann J, Pichersky E, Tholl D Characterization of a root-specific Arabidopsis terpene synthase responsible for the formation of the volatile monoterpene 1,8-cineole Plant Physiology 135 4 1956–1966 August 2004 15299125 520767 10.1104/pp.104.044388 Keszei A, Brubaker CL, Carter R, Köllner T, Degenhardt J, Foley WJ Functional and evolutionary relationships between terpene synthases from Australian Myrtaceae Phytochemistry 71 8–9 844–852 June 2010 20399476 10.1016/j.phytochem.2010.03.013 2010PChem..71..844K This enzyme catalyses the following chemical reaction geranyl diphosphate + H2O 1,8-cineole + diphosphate 500px This enzyme requires Mn2+ or Zn2+. Geranyl diphosphate first isomerizes to (S)-linalyl diphosphate which ionises to the alpha-terpinyl cation which reacts with water to form the product. Rinkel J, Rabe P, Zur Horst L, Dickschat JS A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus Beilstein Journal of Organic Chemistry 12 2317–2324 2016-11-04 28144299 5238540 10.3762/bjoc.12.225 References External links 1,8-cineole+synthase Biology no Category:EC 4.2.3