2-Bromomescaline

Mescaline derivative drug Not to be confused with 2C-B (sometimes also referred to as "bromomescaline") vanc 6 2-Bromomescaline.svg skin-invert-image 225px Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen None correct CAS 37015-19-3 correct FDA A9M89XG7QW 16637783 correct chemspider 17574207 2-BM; 2-Br-M; 2-Bromo-3,4,5-trimethoxyphenethylamine 2-(2-Bromo-3,4,5-trimethoxyphenyl)ethanamine 11 16 1 1 3 COC1=C(C(=C(C(=C1)CCN)Br)OC)OC 1S/C11H16BrNO3/c1-14-8-6-7(4-5-13)9(12)11(16-3)10(8)15-2/h6H,4-5,13H2,1-3H3 UXQBKANLBLUVMK-UHFFFAOYSA-N 2-Bromomescaline (2-BM or 2-Br-M), also known as 2-bromo-3,4,5-trimethoxyphenethylamine, is a putative psychedelic drug of the scaline family and derivative of the phenethylamine hallucinogen mescaline which has an unusual 2-bromo substitution. Shulgin A, Manning T, Daley PF The Shulgin Index. Volume 1. Psychedelic Phenethylamines and Related Compounds 280–281, 355 Transform Press 2011 978-0-9630096-3-0 Pecherer B, Sunbury RC, Brossi A A novel synthesis of aromatic methoxy and methylenedioxy substituted 2,3,4,5-tetrahydro-1H3-benzazepines Journal of Heterocyclic Chemistry June 1972 9 3 609–616 10.1002/jhet.5570090322 It is an agonist for serotonin receptors, with a binding affinity of 215 nM at 5-HT1A, 513 nM at 5-HT2A and 379 nM at 5-HT2C, so while it is around 10times more tightly binding than mescaline at 5-HT1A and 5-HT2A receptors, it is over 20times more potent at 5-HT2C. Trachsel D, Lehmann D, Enzensperger C Phenethylamine Von der Struktur zur Funktion 907–910 Nachtschatten Verlag AG 2013 978-3-03788-700-4 The drug was 5-fold more potent in substituting for LSD than mescaline in rats. It is not known to have been tested in humans. 2-Bromomescaline was first described in the scientific literature, as a chemical intermediate, in 1972. It has been reported as a designer drug, first identified in Austria in January 2023. https://www.euda.europa.eu/sites/default/files/pdf/31883_en.pdf?606797 New psychoactive substances - the current situation in Europe European Drug Report European Union Drugs Agency (EUDA) 2024 The drug is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026 See also Scaline 2,6-Dibromomescaline 2-Chloromescaline 2-Iodomescaline 2-Methylmescaline TeMPEA (2-methoxymescaline) 2-Bromo-TMA 2C-DB DODB 6-Bromo-MDA 6-Chloro-MDMA Bromotomscaline Bromojimscaline References External links 2-Bromomescaline - Isomer Design Category:Bromobenzene derivatives Category:Scalines Category:Serotonin receptor agonists Category:Aminoethyl compounds