15-hydroxyprostaglandin dehydrogenase (NADP+)

Enzyme {{DISPLAYTITLE:15-hydroxyprostaglandin dehydrogenase (NADP+)}} 15-hydroxyprostaglandin dehydrogenase (NADP+) 1.1.1.197 54989-39-8 0047021 In enzymology, 15-hydroxyprostaglandin dehydrogenase (NADP+) (1.1.1.197) is an enzyme that catalyzes the chemical reaction 60% prostaglandin E1 + NADP+ reversible H+ H+ Q27098096 15-oxoprostaglandin E1 + NADPH The two substrates of this enzyme are prostaglandin E1 and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are 15-oxoprostaglandin E1, reduced NADPH, and proton.1.1.1.197Lee SC, Levine L 1975 Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types J. Biol. Chem. 250 548–52 234431 2 10.1016/S0021-9258(19)41931-5 free Lee SC, Pong SS, Katzen D, Wu KY, Levine L 1975 Distribution of prostaglandin E9-ketoreductase and types I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex Biochemistry 14 142–5 803247 10.1021/bi00672a024 1 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase. Other names in common use include NADP+-dependent 15-hydroxyprostaglandin dehydrogenase, NADP+-linked 15-hydroxyprostaglandin dehydrogenase, NADP+-specific 15-hydroxyprostaglandin dehydrogenase, type II 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin dehydrogenase (NADP+). Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PFG. References Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:Enzymes of known structure