411 REFERENCE · Wikipedia
(R)-2-hydroxy-fatty-acid dehydrogenase
Reference material by Wikipedia contributors. This retains its source identity and is not 411 news reporting.
Class of enzymes
(R)-2-hydroxy-fatty-acid dehydrogenase 1.1.1.98 37250-32-1 0047049
In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase (1.1.1.98) is an enzyme that catalyzes the chemical reaction
60% Q27098295 (R)-2-hydroxystearic acid
+ NAD+
reversible H+ H+
Q27104152 2-oxostearic acid
+ NADH
The two substrates of this enzyme are (R)-2-hydroxystearic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-oxostearic acid, reduced NADH, and a proton. This reaction is important in fatty acid metabolism.1.1.1.98 Levis GM 2-Hydroxy fatty acid oxidases of rat kidney Biochemical and Biophysical Research Communications 38 3 470–7 February 1970 5443694 10.1016/0006-291X(70)90737-0 1970BBRC...38..470L
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.
See also
(S)-2-hydroxy-fatty-acid dehydrogenase which acts on the enantiomer of the hydroxy acid.
References
Biology no
Category:EC 1.1.1
Category:NADH-dependent enzymes
Category:Enzymes of unknown structure