2-dehydro-3-deoxygluconokinase

Class of enzymes 2-dehydro-3-deoxygluconokinase 2.7.1.45 9026-54-4 0008673 1v1a.jpg 270 2-Keto-3-deoxygluconate kinase homohexamer, Thermus thermophilus 2-dehydro-3-deoxygluconokinase (2.7.1.45) is an enzyme that catalyzes the chemical reaction 60% ATP + Q27102179 2-dehydro-3-deoxy-D-gluconic acid reversible ADP + Q27098301 2-dehydro-3-deoxy-6-phospho-D-gluconic acid 1.3 The enzyme characterised from Escherichia coli converts 2-dehydro-3-deoxy-D-gluconic acid to 2-dehydro-3-deoxy-6-phospho-D-gluconic acid by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP). Cynkin MA, Ashwell G Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli The Journal of Biological Chemistry 235 1576–9 June 1960 6 10.1016/S0021-9258(19)76843-4 free 13813474 This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 2-keto-3-deoxygluconokinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconokinase (phosphorylating), 2-keto-3-deoxygluconate kinase, and ketodeoxygluconokinase. It participates in the pentose phosphate pathway.2.7.1.45 Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WYE.https://www.rcsb.org/structure/1WYE Toyoda T. Suzuki K. Hossain M.T. Koike I. Sekiguchi T. Takenaka A. Crystal structure of 2-keto-3-deoxygluconate kinase (Form 1) from Sulfolobus Tokodaii 2006 10.2210/pdb1WYE/pdb References Biology no Category:EC 2.7.1 Category:Enzymes of known structure