2-Amino-4-deoxychorismate dehydrogenase

Class of enzymes 2-amino-4-deoxychorismate dehydrogenase 1.3.8.16 2-Amino-4-deoxychorismate dehydrogenase (1.3.8.16, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.Van Lanen SG, Lin S, Shen B Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism Proceedings of the National Academy of Sciences of the United States of America 105 2 494–9 January 2008 18182490 2206564 10.1073/pnas.0708750105 2008PNAS..105..494V free The benzoxazolinate of C-1027 confers intercalative DNA binding Yu L, Mah S, Otani T, Dedon P J. Am. Chem. Soc. 1995 117 34 8877–8878 10.1021/ja00139a032 1995JAChS.117.8877Y This enzyme catalyses the following chemical reaction 60% Q27121525 (1) + FMN forward Q27121523 (2) + FMNH2 It converts 2-amino-2-deoxyisochorismic acid (1) into 3-(1-carboxyvinyloxy)anthranilic acid (2) by oxidation using flavin mononucleotide (FMN) as its cofactor.1.3.99.24 thumb|Antibiotic C-1027 This reaction is part of the biosynthesis of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 from Streptomyces globisporus. The intermediate acid (1) is produced from chorismic acid by the enzyme 2-amino-4-deoxychorismate synthase: 60% chorismic acid + glutamine forward Q27121525 (1) 1.3 + glutamic acid References External links 2-amino-4-deoxychorismate+dehydrogenase Biology no Category:EC 1.3.8