2-Methyl-2,4-pentanediol

changed changed 477214070 2-Methyl-2,4-pentanediol.png 2-Methylpentane-2,4-diol 2-Methyl-2,4-pentanediolHexylene glycolDiolane1,1,3-Trimethyltrimethylenediol2,4-Dihydroxy-2-methylpentaneIsol correct CAS 107-41-5 changed ?? 99210-90-9 (R) changed ?? 99210-91-0 (S) MPD 1098298 changed EBI 62995 changed EBI 2104293 correct chemspider 7582 203-489-0 7870 SA0810000 correct FDA KEH0A3F75J 1993 CC(CC(C)(C)O)O changed chemspider 1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3 changed chemspider SVTBMSDMJJWYQN-UHFFFAOYSA-N 6 14 2 colourless liquid 0.92 g/mL -40 197 miscible mild, sweetish 0.05 mmHg (20°C) 98.3 CDC - NIOSH Pocket Guide to Chemical Hazards none0328 1.3%-7.4% N.D. C 25 ppm (125 mg/m3) Hexylene Glycol https://pubchem.ncbi.nlm.nih.gov/compound/7870#section=Safety-and-Hazards pubchem.ncbi.nlm.nih.gov en 07 Warning 315 319 264 264+265 280 302+352 305+351+338 321 332+317 337+317 362+364 2-Methyl-2,4-pentanediol (MPD) is an organic compound with the formula (CH3)2C(OH)CH2CH(OH)CH3. This colourless liquid is a chiral diol. It is produced industrially from diacetone alcohol by hydrogenation.Stylianos Sifniades, Alan B. Levy, "Acetone" in Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. 10.1002/14356007.a01_079.pub3 Total European and USA production was 15000 tonnes in 2000.SIDS Initial Assessment Report for SIAM 13: Hexylene Glycol 2-Methyl-2,4-pentanediol exists as two enantiomers, (4R)-(−) and (4S)-(+). In the Protein Data Bank, the 3-letter code "MPD" refers to the (S)-(−) enantiomer, while "MRD" is used to refer to the (R)-(+) version. Commercial products labeled "MPD" are usually the racemate,MPD at Hampton Research , MPD Product Page also sold as and referred to as "hexylene glycol".Hexylene Glycol at Sigma Aldrich , Hexylene Glycol Product PageHexylene Glycol at Jena Bioscience, Hexylene Glycol Product Page Uses 2-Methyl-2,4-pentanediol exhibits both surfactant and emulsion-stabilizing properties. Its relatively high viscosity and low volatility are advantageous in coatings, cleansers, cosmetics, solvents, lubricants, and hydraulic fluids.Hexylene glycol chemicalland21.com http://www.chemicalland21.com/industrialchem/solalc/HEXYLENE%20GLYCOL.htm https://web.archive.org/web/20060317205711/http://www.chemicalland21.com/industrialchem/solalc/HEXYLENE%20GLYCOL.htm March 17, 2006 usurped Although it is an irritant at higher concentrations, it is sometimes used in skin care, hair care, soap, and eye cosmetic products at concentrations ranging from 0.1% - 25%. Antibacterial and antifungal properties of propylene glycol, and 1,3-butylene glycol in vitro Kinnunen T. 1991 Acta Dermato-Venereologica 10.2340/0001555571148150 13239472 freeR. Rietschel; J. Fowler; A. Fisher Hexylene Glycol. In Fisher's Contact Dermatitis; Holmes, M., Ed.; BC Decker Inc.: Hamilton, Ontario, 2008; pp 290 It is biodegradable and unlikely to accumulate in the environment.Rhodia Hexylene glycol GPS Safety Summary. 2012. Laboratory uses In the laboratory it is a common precipitant and cryoprotectant in protein crystallography.Crystallization Techniques: Additives, Enrico Stura, University of Glasgow Since hexylene glycol is compatible with polar and nonpolar molecules, it competes with the solvent in a crystallography experiment causing the protein to precipitate. Comparative Effects of Salt, Organic and Polymer Precipitants on Protein Phase Behavior and Implications for Vapor Diffusion Dumetz A. 2009 J. Cryst. Growth 9 2 682–691 10.1021/cg700956b Hexylene glycol is so effective in protein crystallography because its amphiphilic nature and small, flexible structure allows it to bind to many different locations on a protein secondary structure including alpha helices and beta sheets. An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules Anand K 2002 Acta Crystallogr. 58 10 1722–1728 10.1107/s0907444902014610 12351894 7161645 2002AcCrD..58.1722A When hexylene glycol binds to these different locations, water is removed and the protein crystals anneal, which prevents ice formation during cryocrystallography techniques. Thornea Effects of cryoprotectant concentration and cooling rate on vitrification of aqueous solutions Viatcheslav Berejnov 2006 J. Appl. Crystallogr. Incorporation of hexylene glycol into solution has been known to improve the resolution of X-ray diffraction making protein structures easily identifiable. Strategies for Protein Crystallography Vera L 2006 Cryst. Growth Des. Additionally hexylene glycol is not a strong denaturing agent and thus does not significantly alter the structure of a protein during the crystallography procedure. Hexylene glycol is also used as a lubricant for polishing specimens in metallography.https://consumables.alliedhightech.com/GreenLube-p/grnlub.htm GreenLube Allied High Tech 2023-09-23 GreenLube is a medium viscosity hexylene glycol based lubricant used for general metallographic preparation Like related diols, it forms borate esters. References Category:Alkanediols