(heparan sulfate)-glucosamine N-sulfotransferase

Class of enzymes November 2024 [heparan sulfate]-glucosamine N-sulfotransferase 2.8.2.8 9026-75-9 0015016 In enzymology, a [heparan sulfate]-glucosamine N-sulfotransferase (2.8.2.8) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and heparan sulfate-glucosamine, whereas its two products are adenosine 3',5'-bisphosphate and heparan sulfate-N-sulfoglucosamine. This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase. Other names in common use include heparin N-sulfotransferase, 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase, PAPS:N-desulfoheparin sulfotransferase, PAPS:DSH sulfotransferase, N-HSST, N-heparan sulfate sulfotransferase, heparan sulfate N-deacetylase/N-sulfotransferase, heparan sulfate 2-N-sulfotransferase, heparan sulfate N-sulfotransferase, heparan sulfate sulfotransferase, N-desulfoheparin sulfotransferase, desulfoheparin sulfotransferase, 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase, heparitin sulfotransferase, and 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase. References 1 Suzuki S, Trenn RH, Strominger JL 1961 Separation of specific mucopolysaccharide sulfotransferases Biochim. Biophys. Acta 50 169–174 10.1016/0006-3002(61)91075-7 Eisenman RA, Balasubramanian AS, Marx W 1967 3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction Arch. Biochem. Biophys. 119 387–97 4964017 10.1016/0003-9861(67)90470-5 1 Johnson AH, Baker JR 1973 The enzymatic sulphation of heparan sulphate by hen's uterus Biochim. Biophys. Acta 320 341–51 4270798 2 10.1016/0304-4165(73)90314-0 Biology no Category:EC 2.8.2 Category:Enzymes of unknown structure