2-Amino-4-deoxychorismate synthase

Class of enzymes 2-amino-4-deoxychorismate synthase 2.6.1.86 2-amino-4-deoxychorismate synthase (2.6.1.86, ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase. Van Lanen SG, Lin S, Shen B Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism Proceedings of the National Academy of Sciences of the United States of America 105 2 494–9 January 2008 18182490 2206564 10.1073/pnas.0708750105 2008PNAS..105..494V free The benzoxazolinate of C-1027 confers intercalative DNA binding Yu, L. Mah, S. Otani, T. Dedon, P. J. Am. Chem. Soc. 1995 117 34 8877–8878 10.1021/ja00139a032 1995JAChS.117.8877Y McDonald M, Mavrodi DV, Thomashow LS, Floss HG Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid Journal of the American Chemical Society 123 38 9459–60 September 2001 11562236 10.1021/ja011243 Laursen JB, Nielsen J Phenazine natural products: biosynthesis, synthetic analogues, and biological activity Chemical Reviews 104 3 1663–86 March 2004 15008629 10.1021/cr020473j This enzyme catalyses the following chemical reaction thumb|Antibiotic C-1027 This reaction is an early part of the biosynthesis of the benzoxazolinate fragment of the enediyne antitumour antibiotic C-1027 from Streptomyces globisporus. 2-amino-2-deoxyisochorismic acid is produced from chorismic acid by transamination using glutamine as the source of the amino group: 60% chorismic acid + glutamine forward Q27121525 2-amino-2-deoxyisochorismic acid 1.3 + glutamic acid The enzyme requires Mg2+.2.6.1.86 References External links 2-amino-4-deoxychorismate+synthase Biology no Category:EC 2.6.1