2-Aminomuconic acid

Aminomuconic acid.png 200px Skeletal formula of 2-aminomuconic acid 2-Aminomuconic-acid-3D-balls.png 220px Ball-and-stick model of 2-aminomuconic acid (2Z,4E)-2-Aminohexa-2,4-dienedioic acid correct CAS 4548-99-6 C02220 correct FDA 9PX3G8GFQ7 5459864 correct chemspider 4573610 correct EBI 16886 correct chemspider 1S/C6H7NO4/c7-4(6(10)11)2-1-3-5(8)9/h1-3H,7H2,(H,8,9)(H,10,11)/b3-1+,4-2- correct chemspider ZRHONLCTYUYMIQ-TZFCGSKZSA-N C(=C\C(=O)O)/C=C(/C(=O)O)\N C6H7NO4 157.12 g/mol 1.461 g/mL 368.4 2-Aminomuconic acid (also known as 2-aminomuconate) is an unsaturated dicarboxylic amino acid. It is an intermediate in the microbial degradation of aromatic compounds containing nitrogen,Spain Jim C. https://doi.org/10.1007/978-1-4757-9447-2_2 Biodegradation of Nitroaromatic Compounds Springer 1995 978-1-4757-9447-2 Spain Jim C. Environmental Science Research Boston, MA 19-35 Bacterial Degradation of Nitroaromatic Compounds under Aerobic Conditions and also in the kynurenine pathway of tryptophan catabolism. Ichiyama A, Nakamura S, Kawai H, Honjo T, Nishizuka Y, Hayaishi O, Senoh S Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. enzymic formation of alpha-aminomuconic acid from 3-hydroxyanthranilic acid The Journal of Biological Chemistry 240 740–9 February 1965 2 10.1016/S0021-9258(17)45238-0 free 14275130 2-aminomuconic acid has been considered as a biomarker for the evaluation of metabolic dysfunction–associated steatotic liver disease (MASH), with higher levels in the liver correlating with lower disease severity.Das Sandeep Anand Sumit Kumar McKinney M. Peyton Richard Koral S.E. Mahmud Iqbal 2026 Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis https://doi.org/10.1016/j.jhepr.2025.101703 JHEP Reports 2 Dec 2025 8 3 101703 Elsevier Science Direct It has also been used in metabolomic analysis of the response of ovaries to controlled ovarian hyperstimulation.Mu Xin Pei Mei-Li Shi Juan Zi Liu Peijun 2022 Serum Metabolomic Signature Predicts Ovarian Response to Controlled Stimulation https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1882-3967 Hormone and Metabolic Research 7 Sep 2022 54 09 625-632 See also Kynurenine pathway References Category:Dicarboxylic acids Category:Amines