1-phosphofructokinase

InterPro Family Phosphofructokinase 1 1-phosphofructokinase 2.7.1.56 37278-03-8 0008662 2abq.jpg Fructose 1-phosphate kinase homodimer, Bacillus halodurans 1-phosphofructokinase (2.7.1.56) is an enzyme that catalyzes the chemical reaction 60% ATP + Q27104412 fructose 1-phosphate reversible ADP + Q27104462 fructose-1,6-diphosphate 1.3 The enzyme characterised from Aerobacter aerogenes converts D-fructose 1-phosphate (shown in its furanose form) to fructose-1,6-diphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).Reeves RE, Warren LG, Hsu DS 1966 1-Phosphofructokinase from an anaerobe J. Biol. Chem. 241 1257–61 4222878 6 10.1016/S0021-9258(18)96768-2 free Sapico V, Anderson RL 1969 D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties J. Biol. Chem. 244 6280–8 4242639 22 10.1016/S0021-9258(18)63534-3 free This enzyme belongs to the phosphofructokinase B (PfkB) or ribokinase family of sugar kinases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci 2008, 65: 2875-2896.Bork P, Sander C, Valencia A: Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci 1993, 2: 31-40. The systematic name of this enzyme class is ATP:D-fructose-phosphate 6-phosphotransferase. Other names in common use include fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, and 1-phosphofructokinase. This enzyme participates in fructose and mannose metabolism. The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs and their enzymatic activity generally shows a dependence on the presence of pentavalent ions.Maj MC, Singh B, Gupta RS: Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: identification of a novel motif implicated in phosphate and magnesium ion binding and substrate inhibition. Biochemistry 2002, 41: 4059-4069. Structure As of 2021, two structures have been solved for this class of enzymes, with the PDB accession codes 2JG5 and 2ABQ, both from structural genomics efforts. The protein is a homodimer. References Biology no Category:EC 2.7.1 Category:Enzymes of known structure