1976 Zaire Ebola virus outbreak

Outbreak of Ebola virus disease May 2024 1976 Zaire Ebola virus outbreak August–November 1976 Democratic Republic of the Congo (orthographic projection).svg Zaire (orthographic projection) Cases / Deaths: (as at end of outbreak) Zaire: 318 / 280 In August–November 1976, an outbreak of Ebola virus disease occurred in Zaire (now the Democratic Republic of the Congo). The first recorded case was from Yambuku, a small village in Mongala District,Hewlett Barry https://books.google.com/books?id=aboFAAAAQBAJ&q=congo+yambuku&pg=PA103 Ebola, Culture and Politics: The Anthropology of an Emerging Disease Hewlett Bonnie 2007 Cengage Learning 978-1111797317 103 31 July 2014 1098 km mi northeast of the capital city of Kinshasa. The virus responsible for the initial outbreak, named after the nearby Ebola River, was first thought to be Marburg virus but was later identified as a new type of virus related to the genus Marburgvirus.Ebola virus disease https://www.who.int/mediacentre/factsheets/fs103/en/ 15 August 2014 14 December 2014 https://web.archive.org/web/20141214011751/https://www.who.int/mediacentre/factsheets/fs103/en/ live A total of 318 cases and 280 deaths (an 88% fatality rate) resulted from this outbreak, which, along with an outbreak in today's South Sudan that had begun a few weeks previously, were the first outbreaks of Ebola ever recorded.King JW 2 April 2008 Ebola Virus http://www.emedicine.com/MED/topic626.htm 6 October 2008 eMedicine WebMD 28 September 2008 https://web.archive.org/web/20080928063653/http://www.emedicine.com/med/TOPIC626.HTM live History thumb|left|300px|Residents being examined by CDC EIS officers during the Ebola outbreak of 1976 The people of north-central Zaire were most heavily affected by this specific epidemic.2016-11-30 The Outbreak https://www.ncbi.nlm.nih.gov/books/NBK401927/ 2024-06-26 National Academies Press (US) 7 February 2025 https://web.archive.org/web/20250207031005/https://www.ncbi.nlm.nih.gov/books/NBK401927/ live This area is located within the Bumba Zone in the Equator Region, which consists mostly of tropical rainforests in the biome. In 1976, there were approximately 275,000 people in the entire Bumba Zone, including 35,000 Zaireans.Commission Report of an International 1978 Ebola haemorrhagic fever in Zaire, 1976 Bulletin of the World Health Organization Bull World Health Organ 56 2 271–293 0042-9686 307456 2395567 75% of Zaire's population lived in forest villages at that time. Estimates suggest that each of the forest villages had a population of less than 5,000 people; the smallest villages had less than 500 inhabitants. Many of these villages bordered the Zaire River. The river runs along the border on the south side of the country, which was important in the context of the Ebola epidemic because it separated the areas geographically. Most of Zaire's people either hunted or had contact with hunters that were exposed to an array of wild animals.Breman Joel G. Heymann David L. Lloyd Graham McCormick Joseph B. Miatudila Malonga Murphy Frederick A. Muyembé-Tamfun Jean-Jacques Piot Peter Ruppol Jean-François Sureau Pierre van der Groen Guido 29 June 2016 Discovery and Description of Ebola Zaire Virus in 1976 and Relevance to the West African Epidemic During 2013–2016 Journal of Infectious Diseases 214 suppl 3 S93–S101 10.1093/infdis/jiw207 0022-1899 5050466 27357339 This was considered a possible cause of the epidemic for some time; however, it probably was not.Aschengrau Ann Essentials of epidemiology in public health Seage, George R., III 978-1-284-12836-9 Fourth Burlington, MA 1047608336 Because the cause of the outbreak was initially unknown, many people with Ebola virus disease were misdiagnosed and/or treated for malaria, yellow fever, and typhoid fever. Mabalo Lokela, the headmaster of a local school in Yambuku, was the first case of the 1976 outbreak in Zaire.https://www.ft.com/content/4c1711c2-d004-11e3-a2b7-00144feabdc0 https://web.archive.org/web/20250918060601/https://www.ft.com/content/4c1711c2-d004-11e3-a2b7-00144feabdc0 18 September 2025 "Ebola Ground Zero My Journey Back" Financial Times 3 May 2014 Lokela had toured with a Yambuku mission in August 1976 near the Central African Republic border and along the Ebola River.Garrett Laurie Laurie Garrett The Coming Plague: Newly Emerging Diseases in a World of out Balance Virago Press 1994 978-1-86049-211-2 London 100–105 Initially, Lokela was diagnosed with malaria at the Yambuku Mission Hospital and was given quinine. However, Lokela returned to the mission hospital on 1 September with a high fever. Rest was recommended, and he returned home to his village of Yalikonde, about one kilometer from the mission complex. By 5 September, Lokela was in a critical condition with profuse bleeding from all orifices, vomiting, acute diarrhea, chest pains, headache, fever, agitation, and confusion. He died shortly afterwards on 8 September.1978 Ebola hemorrhagic fever in Zaire, 1976 http://whqlibdoc.who.int/bulletin/1978/Vol56-No2/bulletin_1978_56(2)_271-293.pdf dead Bulletin of the World Health Organization 56 6 271 https://web.archive.org/web/20140808213715/http://whqlibdoc.who.int/bulletin/1978/Vol56-No2/bulletin_1978_56%282%29_271-293.pdf 8 August 2014 4 August 2014 On 28 August, another man presented symptoms, claiming he was from the nearby village of Yandongi. He left the hospital on 30 August, as no clear cause could be identified from his symptoms, and was not seen again. On the same day, Yombe Ngongo, a patient at the hospital receiving treatment for anemia, checked out of the hospital and returned to her village. She soon fell seriously ill, and was tended to by her younger sister Euza. Yombe Ngongo died on 7 September, and her sister Euza followed on 9 September. Soon after Lokela's visit, a number of other cases were presented at the Yambuku Mission Hospital. A report from the World Health Organization (WHO) noted that "almost all subsequent infections had either received injections at the hospital or had had close contact with another case." Shortly after family members had prepared his body for burial, in accordance with local customs, 21 of Lokela's friends and relatives all fell seriously ill and 18 later died. Yambuku Mission Hospital was a remote Catholic hospital and had no doctors or laboratory facilities to aid in diagnosis. This, as well as a lack of communication capabilities, contributed to the hospital's isolation from Kinshasa. After the initial Ebola virus disease cases, the hospital was unable to get more resources until the Minister of Health sent out an International Commission to investigate further. Victims received treatment from four Belgian nuns, two Belgian priests, one female nurse from Zaire, and seven male Zaireians. Urgent pleas for assistance were sent out on 12 September. On 15 September, the first doctor to arrive, Mgoi Mushola, prepared a report in which he noted that none of the many treatments provided met with success. This was the first formal description of Ebola virus disease. Epidemiology List of Ebola outbreaks The International Commission team worked with the nurses for interpreting and processing standardized pre-coded forms. These forms included clinical questionnaires, as well as many epidemiological features such as: asking for the sex and age of the person and asking to list out relatives that would also fill out a form. Through this form, the team was able to construct a control group to compare with the Ebola patients, by matching similar traits, thus helping them construct their epidemiological study.The team needed to figure out how this disease was spreading in order to make a plan of attack against the virus.  Because of the uncertainty of the infection route, the team placed a quarantine over the region of the Bumba Zone that was most concerning within two days after the hospital's closure in October. The motivation for this quick quarantine was largely due to the intense nature of the symptoms and rapid progression of this disease. Unfortunately, there was a lot of resistance from people to help out the team and situation because of the fear associated with the unknown infection route of this disease. Since all of the infection route possibilities were in contention, they had to start narrowing down the potential infection pathways. The team noted that the cases had distinct patterns when drawn out into an epidemic curve that showed a clear correlation between the disease and women between the age of 18 and 25. thumb|right|Two nurses treating Mayinga N'Seka, one of the early cases, in 1976 The Mission Hospital had only 120 beds available and a staff of just 17 nurses that were directed by a paramedical assistant, not a doctor. This hospital primarily saw patients from the Yandongi sector, but they had also attracted patients from the outer Bumba Zone because this hospital was considered relatively well-stocked and supplied with a good amount of staff for the area. They were already very limited in disease containment abilities because of these factors, but they also generally saw anywhere between 6,000 and 12,000 patients a month for general care. This is another reason why the quarantine was so necessary during the time of the Ebola epidemic at this hospital.Muyembe T. Kipasa M. June 1995 Ebola haemorrhagic fever in Kikwit, Zaire http://dx.doi.org/10.1016/s0140-6736(95)92640-2 The Lancet 345 8962 1448 10.1016/s0140-6736(95)92640-2 0140-6736 7760645 54363834 subscription 24 December 2022 24 November 2020 https://web.archive.org/web/20221224034220/https://dx.doi.org/10.1016/s0140-6736(95)92640-2 live Peter Piot, a microbiologist and physician who investigated the ensuing epidemic, concluded that it was inadvertently caused by the Sisters of Yambuku Mission Hospital, who had given unnecessary vitamin injections to pregnant women in their prenatal clinic without sterilizing the needles and syringes.Peter Piot 11 August 2014 Part one: A virologist's tale of Africa's first encounter with Ebola https://www.science.org/content/article/part-one-virologists-tale-africas-first-encounter-ebola ScienceInsider 9 October 2014 30 June 2022 https://web.archive.org/web/20141009050901/http://news.sciencemag.org/africa/2014/08/part-one-virologists-tale-africas-first-encounter-ebola live Free accessPeter Piot 13 August 2014 Part two: A virologist's tale of Africa's first encounter with Ebola https://www.science.org/content/article/part-two-virologists-tale-africas-first-encounter-ebola ScienceInsider 16 November 2014 30 June 2022 https://web.archive.org/web/20141116233325/http://news.sciencemag.org/africa/2014/08/part-two-virologists-tale-africas-first-encounter-ebola live Free access There were five total syringes and needles that were being used by this nursing staff for multiple days. These medical materials were rinsed between uses with the use of only warm water. Then, at the end of their shift, the nurses would boil the needles and syringes in water, and no other sterilization methods were utilized. This was not an effective enough sterilization process as the Ebola virus was able to be spread from an initial unidentified infected person and spread through this hospital. The International Commission team was able to back up this theory by their epidemiological study showing a correlation between injection history and Ebola cases and then consequently the spreading through person to person. In all, 318 cases of Ebola were identified in Zaire, and 280 resulted in death. An additional 284 cases and 151 deaths occurred in nearby South Sudan in an unrelated outbreak. Yambuku Mission Hospital was closed after 11 of its 17 staff members died. Belgian nuns serving the community were also infected, and two of them died, along with Mayinga N'Seka, a Zairean nurse, after the group was transported to Kinshasa. With assistance from the WHO, the outbreak was eventually contained by quarantining local villagers in their communities, sterilizing medical equipment, and providing protective clothing to medical personnel. The small Zairian Air Force provided helicopters to allow the outbreak team to visit 550 villages in the area. Cases were documented in 55 of the 550 villages surveyed. The majority of cases were detected in the first four weeks of September, and the last detected probable case died on 5 November 1976. The table below summarizes the eleven outbreaks that have occurred in the DRC since 1976: See also Viruses West African Ebola virus epidemic Ebola virus References Further reading Ngatu Nlandu Roger Kayembe Ntumba Jean-Marie Phillips Elayne Kornblatt Okech-Ojony Joa Patou-Musumari Masika Gaspard-Kibukusa Mukunda Madone-Mandina Ndona Godefroid-Mayala Mabasi Mutaawe Lubogo Manzengo Casimir Roger-Wumba Dimosi Nojima Sayumi 13 April 2017 Epidemiology of ebolavirus disease (EVD) and occupational EVD in health care workers in Sub-Saharan Africa: Need for strengthened public health preparedness Journal of Epidemiology 27 10 455–461 10.1016/j.je.2016.09.010 1349-9092 5602796 28416172 29 June 2016 Analysis of 1976 Ebola outbreak holds lessons relevant today https://www.nih.gov/news-events/analysis-1976-ebola-outbreak-holds-lessons-relevant-today dead https://web.archive.org/web/20160701111847/https://www.nih.gov/news-events/analysis-1976-ebola-outbreak-holds-lessons-relevant-today 1 July 2016 29 June 2016 National Institute of Health NIH.gov disease Category:1976 in Zaire Category:August 1976 in Africa Zaire Ebola