16β-Hydroxyestrone

16beta-hydroxyestrone.svg skin-invert-image 200px 3,16β-Dihydroxyestra-1,3,5(10)-trien-17-one (2S,3aS,3bR,9bS,11aS)-2,7-Dihydroxy-11a-methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthren-1-one 16β-OH-E1 966-06-3 87628 1908079 17215934 1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-16,19-20H,2,4,6-7,9H2,1H3/t13-,14-,15+,16+,18+/m1/s1 WPOCIZJTELRQMF-LFRCEIEQSA-N 22833517 Oc1ccc2[C@H]3CC[C@]4(C)C([C@]6C[C@H]4[C@@H]3CCc2c1)=O.O6 18 22 3 16β-Hydroxyestrone (16β-OH-E1) is an endogenous estrogen which serves as a metabolite of estrone as well as a metabolic intermediate in the transformation of estrone into epiestriol (16β-hydroxyestradiol). https://pubchem.ncbi.nlm.nih.gov/compound/22833517 16beta-Hydroxyestrone PubChem Hormonal Steroids Biochemistry, Pharmacology, and Therapeutics Velardo Joseph Thomas The Actions of Steroid Hormones on Estradiol-17β in Uterine Growth and Enzymorphology 1964 463–490 10.1016/B978-0-12-395506-7.50065-0 16β-Hydroxyestrone has similar estrogenic activity to that of 16α-hydroxyestrone. It is less potent than estradiol or estrone but can produce similar maximal uterotrophy at sufficiently high doses, suggesting a fully estrogenic profile. See also 16-Ketoestrone References Category:Estranes Category:Estrogens Category:Human metabolites Category:Hydroxyarenes